C57BL/6JCya-Ankrd13dem1flox/Cya
Common Name
Ankrd13d-flox
Product ID
S-CKO-19481
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-68423-Ankrd13d-B6J-VB
Status
When using this mouse strain in a publication, please cite “Ankrd13d-flox Mouse (Catalog S-CKO-19481) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ankrd13d-flox
Strain ID
CKOCMP-68423-Ankrd13d-B6J-VB
Gene Name
Product ID
S-CKO-19481
Gene Alias
0710001P18Rik
Background
C57BL/6JCya
Gene Full Name
ankyrin repeat domain 13 family, member D
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 19 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000056888
NCBI Transcript ID
NM_026720
Target Region
Exon 2~6
Size of Effective Region
~2.3 kb
Overview of Gene Research
Ankrd13d, ankyrin repeat domain-containing protein 13D, may be involved in multiple biological processes. It contains ubiquitin-interacting motifs (UIM) and is part of the endocytic pathway, which plays a crucial role in various cellular functions [2,3].
Research has linked Ankrd13d to several diseases. In renal cell carcinoma, it was identified as a key immune regulator, mainly expressed in immune cells and positively correlated with Treg cell infiltration. Targeting it with immune checkpoints blockade might be a strategy for immunotherapy [1]. In Alzheimer's disease, rare variants in Ankrd13d were associated with the disease, its related phenotypes, and functional consequences [3]. It was also identified in relation to incident heart failure with reduced ejection fraction [4], and in Hispanic Americans, novel signals for arachidonic acid were found in/near the Ankrd13d gene [5,6]. Additionally, in clear cell renal cell carcinoma, it has a strong positive correlation with TRIM46 [7].
In conclusion, Ankrd13d appears to be involved in multiple disease-related biological processes, such as immune regulation in renal cell carcinoma, the endocytic pathway in Alzheimer's disease, and heart failure development. These associations suggest that Ankrd13d could be a potential biomarker or therapeutic target in these diseases, though further in-vivo studies like gene knockout (KO) or conditional knockout (CKO) mouse models are likely needed to fully understand its functions and roles in these disease conditions.
References：
1. Zhou, Wenqian, Huang, Yonghe, Liu, Jing, Liu, Yuqing, Yu, Chen. 2024. Identification of ANKRD13D as a potential target in renal cell carcinomas. In The International journal of biological markers, 39, 149-157. doi:10.1177/03936155241236498. https://pubmed.ncbi.nlm.nih.gov/38449090/
2. Mattioni, Anna, Boldt, Karsten, Auciello, Giulio, Cesareni, Gianni, Santonico, Elena. 2020. Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family. In The FEBS journal, 287, 3526-3550. doi:10.1111/febs.15226. https://pubmed.ncbi.nlm.nih.gov/31985874/
3. Zhan, Lingyu, Li, Jiajin, Jew, Brandon, Sul, Jae Hoon. 2021. Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. In PLoS genetics, 17, e1009772. doi:10.1371/journal.pgen.1009772. https://pubmed.ncbi.nlm.nih.gov/34516545/
4. Andersson, Charlotte, Lin, Honghuang, Liu, Chunyu, Larson, Martin G, Vasan, Ramachandran S. 2019. Integrated Multiomics Approach to Identify Genetic Underpinnings of Heart Failure and Its Echocardiographic Precursors: Framingham Heart Study. In Circulation. Genomic and precision medicine, 12, e002489. doi:10.1161/CIRCGEN.118.002489. https://pubmed.ncbi.nlm.nih.gov/31703168/
5. Yang, Chaojie, Veenstra, Jenna, Bartz, Traci M, Lemaitre, Rozenn N, Manichaikul, Ani. 2023. Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts. In Communications biology, 6, 852. doi:10.1038/s42003-023-05219-w. https://pubmed.ncbi.nlm.nih.gov/37587153/
6. Yang, Chaojie, Veenstra, Jenna, Bartz, Traci, Lemaitre, Rozenn, Manichaikul, Ani. 2023. Genome-Wide Association Studies and fine-mapping of genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts. In Research square, , . doi:10.21203/rs.3.rs-2073736/v1. https://pubmed.ncbi.nlm.nih.gov/36865120/
7. Ren, Xiang-Bin, Zhao, Jing, Liang, Xue-Feng, Jiang, Shao-Bo, Xiang, Yu-Zhu. 2021. Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses. In Frontiers in medicine, 8, 785331. doi:10.3389/fmed.2021.785331. https://pubmed.ncbi.nlm.nih.gov/34881275/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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