C57BL/6JCya-Ankrd13dem1flox/Cya
Common Name:
Ankrd13d-flox
Product ID:
S-CKO-19481
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ankrd13d-flox
Strain ID
CKOCMP-68423-Ankrd13d-B6J-VB
Gene Name
Product ID
S-CKO-19481
Gene Alias
0710001P18Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
19
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ankrd13dem1flox/Cya mice (Catalog S-CKO-19481) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000056888
NCBI RefSeq
NM_026720
Target Region
Exon 2~6
Size of Effective Region
~2.3 kb
Detailed Document
Overview of Gene Research
Ankrd13d, ankyrin repeat domain-containing protein 13D, may be involved in multiple biological processes. It contains ubiquitin-interacting motifs (UIM) and is part of the endocytic pathway, which plays a crucial role in various cellular functions [2,3].
Research has linked Ankrd13d to several diseases. In renal cell carcinoma, it was identified as a key immune regulator, mainly expressed in immune cells and positively correlated with Treg cell infiltration. Targeting it with immune checkpoints blockade might be a strategy for immunotherapy [1]. In Alzheimer's disease, rare variants in Ankrd13d were associated with the disease, its related phenotypes, and functional consequences [3]. It was also identified in relation to incident heart failure with reduced ejection fraction [4], and in Hispanic Americans, novel signals for arachidonic acid were found in/near the Ankrd13d gene [5,6]. Additionally, in clear cell renal cell carcinoma, it has a strong positive correlation with TRIM46 [7].
In conclusion, Ankrd13d appears to be involved in multiple disease-related biological processes, such as immune regulation in renal cell carcinoma, the endocytic pathway in Alzheimer's disease, and heart failure development. These associations suggest that Ankrd13d could be a potential biomarker or therapeutic target in these diseases, though further in-vivo studies like gene knockout (KO) or conditional knockout (CKO) mouse models are likely needed to fully understand its functions and roles in these disease conditions.
References:
1. Zhou, Wenqian, Huang, Yonghe, Liu, Jing, Liu, Yuqing, Yu, Chen. 2024. Identification of ANKRD13D as a potential target in renal cell carcinomas. In The International journal of biological markers, 39, 149-157. doi:10.1177/03936155241236498. https://pubmed.ncbi.nlm.nih.gov/38449090/
2. Mattioni, Anna, Boldt, Karsten, Auciello, Giulio, Cesareni, Gianni, Santonico, Elena. 2020. Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family. In The FEBS journal, 287, 3526-3550. doi:10.1111/febs.15226. https://pubmed.ncbi.nlm.nih.gov/31985874/
3. Zhan, Lingyu, Li, Jiajin, Jew, Brandon, Sul, Jae Hoon. 2021. Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. In PLoS genetics, 17, e1009772. doi:10.1371/journal.pgen.1009772. https://pubmed.ncbi.nlm.nih.gov/34516545/
4. Andersson, Charlotte, Lin, Honghuang, Liu, Chunyu, Larson, Martin G, Vasan, Ramachandran S. 2019. Integrated Multiomics Approach to Identify Genetic Underpinnings of Heart Failure and Its Echocardiographic Precursors: Framingham Heart Study. In Circulation. Genomic and precision medicine, 12, e002489. doi:10.1161/CIRCGEN.118.002489. https://pubmed.ncbi.nlm.nih.gov/31703168/
5. Yang, Chaojie, Veenstra, Jenna, Bartz, Traci M, Lemaitre, Rozenn N, Manichaikul, Ani. 2023. Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts. In Communications biology, 6, 852. doi:10.1038/s42003-023-05219-w. https://pubmed.ncbi.nlm.nih.gov/37587153/
6. Yang, Chaojie, Veenstra, Jenna, Bartz, Traci, Lemaitre, Rozenn, Manichaikul, Ani. 2023. Genome-Wide Association Studies and fine-mapping of genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts. In Research square, , . doi:10.21203/rs.3.rs-2073736/v1. https://pubmed.ncbi.nlm.nih.gov/36865120/
7. Ren, Xiang-Bin, Zhao, Jing, Liang, Xue-Feng, Jiang, Shao-Bo, Xiang, Yu-Zhu. 2021. Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses. In Frontiers in medicine, 8, 785331. doi:10.3389/fmed.2021.785331. https://pubmed.ncbi.nlm.nih.gov/34881275/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen