Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Apohem1flox/Cya
Common Name:
Apoh-flox
Product ID:
S-CKO-19497
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Apoh-flox
Strain ID
CKOCMP-11818-Apoh-B6J-VB
Gene Name
Apoh
Product ID
S-CKO-19497
Gene Alias
B2GPI; beta-2-GPI; beta2-GPI
Background
C57BL/6JCya
NCBI ID
11818
Modification
Conditional knockout
Chromosome
11
Phenotype
MGI:88058
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Apohem1flox/Cya mice (Catalog S-CKO-19497) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000000049
NCBI RefSeq
NM_013475
Target Region
Exon 3
Size of Effective Region
~0.9 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Apoh, also known as apolipoprotein H, is involved in lipid metabolism, regulating triglycerides, and has a role in pathways related to complement and coagulation regulation [3,6,7]. It is one of the apolipoproteins that can bind free fatty acids, regulate the activity of many proteins involved in HDL metabolism, inhibit lipid transfer, and control the endogenous coagulation cascade [5].

In antiphospholipid syndrome (APS), both exosomes containing APOH (APOH-exos) and APS-exos impair vascular development and lead to pregnancy complications. APOH-exos may be key in the pathogenesis of APS as they can directly enter human umbilical vein endothelial cells (HUVECs) and may act through the phospho-extracellular signal-regulated kinase pathway [1]. Also, in APS patients, polymorphisms in the APOH gene (rs1801690, rs52797880, and rs8178847) are associated with susceptibility to recurrent pregnancy loss (RPL) [2].

In type 2 diabetic patients, APOH plasma levels are associated with metabolic syndrome (MS) alterations and vascular disease, with enhanced levels due to increased liver synthesis [3]. In diabetic kidney disease, the mRNA expression level of Apoh was declined [4]. In Influenza infection, low plasma levels of ApoH are associated with a worse prognosis and respiratory failure [7].

In conclusion, Apoh is crucial in lipid metabolism, complement and coagulation regulation. Its study through various models has revealed its significant roles in diseases such as APS, type 2 diabetes, diabetic kidney disease, and influenza infection. Understanding Apoh's functions can potentially provide new therapeutic targets for these diseases.

References:
1. Tan, Yuan, Bian, Yiding, Song, Yunfeng, Zhang, Qinhua, Wan, Xiaoping. 2021. Exosome-Contained APOH Associated With Antiphospholipid Syndrome. In Frontiers in immunology, 12, 604222. doi:10.3389/fimmu.2021.604222. https://pubmed.ncbi.nlm.nih.gov/34040601/
2. Deng, Xujing, Sang, Qing, Zhang, Ruixiu, Mu, Jian, Bao, Shihua. 2023. The association of APOH and NCF1 polymorphisms on susceptibility to recurrent pregnancy loss in women with antiphospholipid syndrome. In Journal of assisted reproduction and genetics, 40, 1703-1712. doi:10.1007/s10815-023-02829-5. https://pubmed.ncbi.nlm.nih.gov/37243946/
3. Castro, Antoni, Lázaro, Iolanda, Selva, David M, Simó, Rafael, Masana, Lluís. 2009. APOH is increased in the plasma and liver of type 2 diabetic patients with metabolic syndrome. In Atherosclerosis, 209, 201-5. doi:10.1016/j.atherosclerosis.2009.09.072. https://pubmed.ncbi.nlm.nih.gov/19878946/
4. Zhao, Jing, He, Kaiying, Du, Hongxuan, Zhou, Xiaochun, Wang, Jianqin. 2022. Bioinformatics prediction and experimental verification of key biomarkers for diabetic kidney disease based on transcriptome sequencing in mice. In PeerJ, 10, e13932. doi:10.7717/peerj.13932. https://pubmed.ncbi.nlm.nih.gov/36157062/
5. Deng, Siying, Xu, Yangkai, Zheng, Lemin. . HDL Structure. In Advances in experimental medicine and biology, 1377, 1-11. doi:10.1007/978-981-19-1592-5_1. https://pubmed.ncbi.nlm.nih.gov/35575917/
6. Gu, W, Ray, K, Pearce-Kelling, S, Acland, G M, Aguirre, G D. . Evaluation of the APOH gene as a positional candidate for prcd in dogs. In Investigative ophthalmology & visual science, 40, 1229-37. doi:. https://pubmed.ncbi.nlm.nih.gov/10235557/
7. Garcinuño, Sara, Lalueza, Antonio, Gil-Etayo, Francisco Javier, Serrano, Antonio, Serrano, Manuel. 2024. Immune dysregulation is an important factor in the underlying complications in Influenza infection. ApoH, IL-8 and IL-15 as markers of prognosis. In Frontiers in immunology, 15, 1443096. doi:10.3389/fimmu.2024.1443096. https://pubmed.ncbi.nlm.nih.gov/39176097/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest