C57BL/6JCya-Krtap10-4em1/Cya
Common Name:
Krtap10-4-KO
Product ID:
S-KO-00080
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Krtap10-4-KO
Strain ID
KOCMP-100191037-Krtap10-4-B6J-VA
Gene Name
Product ID
S-KO-00080
Gene Alias
675238; A030009A09Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Krtap10-4em1/Cya mice (Catalog S-KO-00080) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000092369
NCBI RefSeq
NM_001135991.1
Target Region
Exon 1
Size of Effective Region
~2.3 kb
Detailed Document
Overview of Gene Research
Krtap10-4 is a gene that has been newly associated with major adverse cardiovascular events (MACE). However, the provided abstract does not detail its essential function, associated pathways, or overall biological importance. Genetic models could potentially be valuable in further exploring these aspects of Krtap10-4.
A study identified Krtap10-4 (rs201441480) as one of eight new genotypes and their associated genes related to MACE in patients with acute coronary syndromes (ACS). This discovery was made through a two-stage large-scale sequencing data analysis, including high-depth whole exome sequencing in a discovery cohort and high-depth targeted sequencing in a replication cohort [1].
In conclusion, while the exact biological functions of Krtap10-4 are yet to be fully elucidated, its association with MACE in ACS patients discovered through genetic sequencing in this study indicates its potential importance in cardiovascular-related disease areas. Further in vivo studies, such as gene knockout (KO) or conditional knockout (CKO) mouse models, could be used to better understand its role in these disease processes. [1]
References:
1. Liu, Xiaomin, Xu, Hanshi, Xu, Huaiqian, Liu, Xiao, Zhong, Shilong. 2021. New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin. In The pharmacogenomics journal, 21, 664-672. doi:10.1038/s41397-021-00245-5. https://pubmed.ncbi.nlm.nih.gov/34158603/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen