Jkamp, also known as JNK1-associated membrane protein, is involved in multiple biological processes. It is related to the Wnt signaling pathway and plays a role in the osteogenic differentiation of adipose-derived stem cells (ASCs). It also may be associated with endoplasmic reticulum-associated degradation (ERAD) and the regulation of G protein-coupled receptor (GPCR) stability [1,3,4].

In diabetic osteoporosis, the expression of Jkamp in ASCs from DOP mice is decreased. Intragenic DNA methylation inhibits the osteogenic ability of DOP-ASCs by suppressing Jkamp expression and the Wnt signaling pathway. Silencing Jkamp in normal ASCs inhibits the Wnt signaling pathway and reduces osteogenic ability, while overexpressing Jkamp in DOP-ASCs can rescue the impaired osteogenic capacity [1]. In type 1 diabetic cardiomyopathy, Jkamp is identified as one of the endoplasmic reticulum stress-related diagnostic biomarkers [2].

In conclusion, Jkamp is important in processes like osteogenic differentiation and may be a diagnostic biomarker in certain diseases. Studies, especially those related to gene expression changes in disease-relevant cell models, help to reveal its role in diabetic osteoporosis and type 1 diabetic cardiomyopathy, providing potential therapeutic targets and new insights for diagnosis and treatment [1,2].

References:

1. Peng, Shuanglin, Shi, Sirong, Tao, Gang, Cai, Xiaoxiao, Xiao, Jingang. 2021. JKAMP inhibits the osteogenic capacity of adipose-derived stem cells in diabetic osteoporosis by modulating the Wnt signaling pathway through intragenic DNA methylation. In Stem cell research & therapy, 12, 120. doi:10.1186/s13287-021-02163-6. https://pubmed.ncbi.nlm.nih.gov/33579371/

2. Tang, Qiao, Ji, Yanwei, Xia, Zhongyuan, Sun, Qian, Lei, Shaoqing. 2025. Identification and validation of endoplasmic reticulum stress-related diagnostic biomarkers for type 1 diabetic cardiomyopathy based on bioinformatics and machine learning. In Frontiers in endocrinology, 16, 1478139. doi:10.3389/fendo.2025.1478139. https://pubmed.ncbi.nlm.nih.gov/40171194/

3. Tcherpakov, Marianna, Delaunay, Agnes, Toth, Julia, Petroski, Matthew D, Ronai, Ze'ev A. 2009. Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP). In The Journal of biological chemistry, 284, 12099-109. doi:10.1074/jbc.M808222200. https://pubmed.ncbi.nlm.nih.gov/19269966/

4. Roy, Sébastien J, Glazkova, Irina, Fréchette, Louis, Hébert, Terence E, Parent, Jean-Luc. 2013. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. In Molecular endocrinology (Baltimore, Md.), 27, 1245-66. doi:10.1210/me.2013-1091. https://pubmed.ncbi.nlm.nih.gov/23798571/