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C57BL/6JCya-Lmf2em1/Cya
Common Name:
Lmf2-KO
Product ID:
S-KO-00426
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Lmf2-KO
Strain ID
KOCMP-105847-Lmf2-B6J-VA
Gene Name
Lmf2
Product ID
S-KO-00426
Gene Alias
Tmem112b; Tmem153
Background
C57BL/6JCya
NCBI ID
105847
Modification
Conventional knockout
Chromosome
15
Phenotype
MGI:2146015
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lmf2em1/Cya mice (Catalog S-KO-00426) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000023283
NCBI RefSeq
NM_178919
Target Region
Exon 6~14
Size of Effective Region
~2.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Lmf2, or Lipase maturation factor 2, is a member of the LMF family proteins. These proteins are essential for the maturation and transport of active lipoprotein lipases, suggesting Lmf2 plays a role in lipid metabolism pathways [2].

In Alzheimer's disease (AD) and amnesic mild cognitive impairment (aMCI), DNA methylation levels in the NCAPH2/LMF2 promoter region are significantly decreased compared to normal controls, potentially serving as a biomarker for diagnosis [3]. Moreover, this methylation is associated with hippocampal atrophy in AD and aMCI patients, possibly through apoptosis [1]. In the grain aphid, silencing of a lmf2-like gene by wheat-mediated RNAi reduces the aphid's survivability and reproductive capacity, indicating its importance in aphid growth and reproduction [2]. Also, a burden of rare predicted loss-of-function (pLOF) variants in Lmf2 is associated with increased hepatic fat [4]. In sheep, Lmf2 is involved in fast metabolism, and its associated copy number variations (CNVs) are associated with climatic variables, suggesting a role in climate-related adaptation [5].

In summary, Lmf2 is crucial for lipoprotein lipase maturation and has implications in multiple biological processes and disease conditions. Its role in lipid metabolism, as well as its associations with AD, aMCI, aphid survival, hepatic fat, and sheep metabolism adaptation, underscores its significance. The study of Lmf2 using genetic models like RNAi in aphids and identification of genetic variants in humans and sheep, helps in understanding its functions and disease associations.

References:

1. Shinagawa, Shunichiro, Kobayashi, Nobuyuki, Nagata, Tomoyuki, Kondo, Kazuhiro, Nakayama, Kazuhiko. 2016. DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy in Alzheimer's disease and amnesic mild cognitive impairment patients. In Neuroscience letters, 629, 33-37. doi:10.1016/j.neulet.2016.06.055. https://pubmed.ncbi.nlm.nih.gov/27356276/

2. Xu, Lanjie, Hou, Qiling, Zhao, Yanjie, Ni, Zhongfu, Liang, Rongqi. 2017. Silencing of a lipase maturation factor 2-like gene by wheat-mediated RNAi reduces the survivability and reproductive capacity of the grain aphid, Sitobion avenae. In Archives of insect biochemistry and physiology, 95, . doi:10.1002/arch.21392. https://pubmed.ncbi.nlm.nih.gov/28618004/

3. Kobayashi, Nobuyuki, Shinagawa, Shunichiro, Nagata, Tomoyuki, Nakayama, Kazuhiko, Kondo, Kazuhiro. 2016. Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment. In PloS one, 11, e0146449. doi:10.1371/journal.pone.0146449. https://pubmed.ncbi.nlm.nih.gov/26742120/

4. Park, Joseph, MacLean, Matthew T, Lucas, Anastasia M, Witschey, Walter R, Rader, Daniel J. 2022. Exome-wide association analysis of CT imaging-derived hepatic fat in a medical biobank. In Cell reports. Medicine, 3, 100855. doi:10.1016/j.xcrm.2022.100855. https://pubmed.ncbi.nlm.nih.gov/36513072/

5. Salehian-Dehkordi, Hosein, Huang, Jia-Hui, Pirany, Nasrollah, Esmailizadeh, Ali, Lv, Feng-Hua. 2023. Genomic Landscape of Copy Number Variations and Their Associations with Climatic Variables in the World's Sheep. In Genes, 14, . doi:10.3390/genes14061256. https://pubmed.ncbi.nlm.nih.gov/37372436/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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