YPEL1, a member of the YPEL (Yippee-like) gene family, is a nuclear protein involved in various cellular processes. It has been implicated in cell cycle regulation, senescence, and mammalian development [3]. YPEL1 may also play roles in multiple signaling pathways, though specific pathways are not comprehensively detailed across these references. Its biological importance spans from embryonic development to cancer-related processes. Genetic models, such as mouse models, could potentially provide further insights into its functions.

In human mucociliary differentiation, YPEL1 is a marker for a precursor subgroup of multiciliated cells called deuterosomal cells [1]. In avian craniofacial development, overexpression of YPEL1 causes abnormal mandibular morphogenesis associated with increased apoptosis and involvement of the BMP/MSX pathway [2]. In NK/T cell lymphomas, knocking down YPEL1 in cell lines induces apoptosis and autophagy, and reduces tumor growth in a xenograft model [3]. In gastric cancer, miR-885-5p promotes cancer cell proliferation and invasion by regulating YPEL1 [4]. In glioma, low YPEL1 expression is correlated with poor overall survival, and overexpressing YPEL1 can prevent glioma cell proliferation and invasion [5]. In pancreatic cancer, reduced expression of YPEL1 might be related to perineural invasion and prognosis [6].

In conclusion, YPEL1 is involved in crucial biological processes such as cell differentiation during development and is associated with multiple disease conditions including cancer. Findings from various experimental models, though not always from KO/CKO mouse models, have enhanced our understanding of its role in these processes. The study of YPEL1 provides potential insights into the mechanisms of development and disease, offering possibilities for novel therapeutic strategies.

References:

1. Ruiz García, Sandra, Deprez, Marie, Lebrigand, Kevin, Barbry, Pascal, Zaragosi, Laure-Emmanuelle. 2019. Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures. In Development (Cambridge, England), 146, . doi:10.1242/dev.177428. https://pubmed.ncbi.nlm.nih.gov/31558434/

2. Tan, Tiong Yang, Gordon, Christopher T, Miller, Kerry A, Amor, David J, Farlie, Peter G. 2015. YPEL1 overexpression in early avian craniofacial mesenchyme causes mandibular dysmorphogenesis by up-regulating apoptosis. In Developmental dynamics : an official publication of the American Association of Anatomists, 244, 1022-30. doi:10.1002/dvdy.24299. https://pubmed.ncbi.nlm.nih.gov/26061551/

3. Wang, Miao, Qian, Siyu, Zhang, Yue, Zhang, Xudong, Zhang, Mingzhi. 2025. YPEL1 Inhibits Development of Gemcitabine Resistance in NK / T Cell Lymphomas. In Current cancer drug targets, , . doi:10.2174/0115680096328745250122231110. https://pubmed.ncbi.nlm.nih.gov/40103457/

4. Li, S, Sun, M-Y, Su, X. . MiR-885-5p promotes gastric cancer proliferation and invasion through regulating YPEL1. In European review for medical and pharmacological sciences, 23, 7913-7919. doi:10.26355/eurrev_201909_19005. https://pubmed.ncbi.nlm.nih.gov/31599416/

5. Li, Weimin, Huang, Wei, Wu, Ke, Long, Yong. . Yippee Like 1 Suppresses Glioma Progression and Serves as a Novel Prognostic Factor. In The Tohoku journal of experimental medicine, 256, 141-150. doi:10.1620/tjem.256.141. https://pubmed.ncbi.nlm.nih.gov/35185081/

6. Abiatari, I, Kiladze, M, Kerkadze, V, Friess, H, Kleeff, J. . Expression of YPEL1 in pancreatic cancer cell lines and tissues. In Georgian medical news, , 60-2. doi:. https://pubmed.ncbi.nlm.nih.gov/19893129/