C57BL/6JCya-Gramd2bem1/Cya
Common Name:
Gramd2b-KO
Product ID:
S-KO-00481
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Gramd2b-KO
Strain ID
KOCMP-107022-Gramd2b-B6J-VA
Gene Name
Product ID
S-KO-00481
Gene Alias
9030613F08Rik; 9130427A09Rik; Gramd3; NS3TP2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
18
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gramd2bem1/Cya mice (Catalog S-KO-00481) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000237422
NCBI RefSeq
NM_001360917
Target Region
Exon 2~5
Size of Effective Region
~9.4 kb
Detailed Document
Overview of Gene Research
GRAMD2B, whose full name might not be as commonly known, is a gene. However, based on the reference, its function seems to be associated with the regulation of serum leucocyte concentration [1]. While the reference doesn't elaborate on the exact associated pathways, it indicates a potential role in processes related to the immune system considering the leucocyte connection. Genetic models, such as KO/CKO mouse models, could potentially be valuable in further exploring its functions.
In a genome-wide association study on coronary artery disease in type 1 diabetes, among eight suggestive loci, the rs2112481 on the GRAMD2B promoter was associated with serum leucocyte concentration [1]. This finding implies that GRAMD2B might play a role in the context of type 1 diabetes-related coronary artery disease, potentially through its influence on leucocyte levels.
In conclusion, GRAMD2B appears to have a function related to the regulation of serum leucocyte concentration, which may be relevant in the context of type 1 diabetes-associated coronary artery disease. The discovery in the study provides a starting point for further in-vivo studies, especially using KO/CKO mouse models, to better understand its role in these disease-related biological processes.
References:
1. Antikainen, Anni A V, Sandholm, Niina, Trégouët, David-Alexandre, Rossing, Peter, Groop, Per-Henrik. . Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus. In Cardiovascular research, 117, 600-612. doi:10.1093/cvr/cvaa045. https://pubmed.ncbi.nlm.nih.gov/32077919/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen