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C57BL/6JCya-Slc35b3em1/Cya
Common Name:
Slc35b3-KO
Product ID:
S-KO-00602
Background:
C57BL/6JCya
Product Type
Age
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Sex
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Basic Information
Strain Name
Slc35b3-KO
Strain ID
KOCMP-108652-Slc35b3-B6J-VA
Gene Name
Slc35b3
Product ID
S-KO-00602
Gene Alias
4921526O06Rik; CGI-19; PABST2; PAPST2
Background
C57BL/6JCya
NCBI ID
108652
Modification
Conventional knockout
Chromosome
13
Phenotype
MGI:1913978
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc35b3em1/Cya mice (Catalog S-KO-00602) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000021870
NCBI RefSeq
NM_001170431
Target Region
Exon 2~8
Size of Effective Region
~18.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Slc35b3, known as solute carrier family 35 member B3, is a transferase involved in the synthesis of 3'-phosphoadenosine-5'-phosphosulfate (PAPS), which plays a key role in mucin sulfation [1]. It is part of the aryl hydrocarbon receptor (AHR)-Papss2-Slc35b3 pathway, contributing to the maintenance of intestinal epithelial homeostasis [1].

In a study on inflammatory bowel disease (IBD), a high-fat diet (HFD) led to a decrease in indole-3-acetic acid (IAA) and intestinal barrier damage. IAA supplementation enhanced intestinal mucin sulfation and alleviated colitis by upregulating Papss2 and Slc35b3 via the AHR [1]. Oral administration of Lactobacillus reuteri, which produces IAA, protected against colitis and promoted mucin sulfation, while a modified strain lacking the ability to produce IAA did not [1]. In addition, in non-small cell lung cancer (NSCLC), there were nominally significant associations between copy number variations (CNVs) and the SLC35B3 gene [2]. Also, in muscle-invasive bladder cancer, a 9-gene signature including SLC35B3 could predict response to neoadjuvant chemotherapy [3].

In conclusion, Slc35b3 is crucial for maintaining intestinal epithelial homeostasis through its role in mucin sulfation. Its upregulation by IAA via the AHR pathway has implications for IBD treatment. Additionally, the associations of SLC35B3 with CNVs in NSCLC and its role in predicting chemotherapy response in muscle-invasive bladder cancer suggest its significance in cancer-related research.

References:

1. Li, Mengfan, Ding, Yiyun, Wei, Jingge, Su, Xiaomin, Cao, Hailong. 2024. Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation. In Gut microbes, 16, 2377576. doi:10.1080/19490976.2024.2377576. https://pubmed.ncbi.nlm.nih.gov/39068517/

2. Heo, Yeonjeong, Heo, Jeongwon, Han, Seon-Sook, Cheong, Hyun Sub, Hong, Yoonki. 2020. Difference of copy number variation in blood of patients with lung cancer. In The International journal of biological markers, 36, 3-9. doi:10.1177/1724600820980739. https://pubmed.ncbi.nlm.nih.gov/33307925/

3. Hepburn, Anastasia C, Lazzarini, Nicola, Veeratterapillay, Rajan, Bacardit, Jaume, Heer, Rakesh. 2021. Identification of CNGB1 as a Predictor of Response to Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer. In Cancers, 13, . doi:10.3390/cancers13153903. https://pubmed.ncbi.nlm.nih.gov/34359804/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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