Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Adipoqem1/Cya
Common Name:
Adipoq-KO
Product ID:
S-KO-00862
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Adipoq-KO
Strain ID
KOCMP-11450-Adipoq-B6N-VA
Gene Name
Adipoq
Product ID
S-KO-00862
Gene Alias
30kDa; APN; Acdc; Acrp30; Ad; Adid; GBP28; adipo; apM1
Background
C57BL/6NCya
NCBI ID
11450
Modification
Conventional knockout
Chromosome
16
Phenotype
MGI:106675
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Adipoqem1/Cya mice (Catalog S-KO-00862) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000023593
NCBI RefSeq
NM_009605
Target Region
Exon 2~3
Size of Effective Region
~2.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Adipoq, encoding adiponectin, is a fat-derived protein hormone gene. Adiponectin plays a preponderant role in glucose and fatty acid homeostasis, and is involved in multiple pathways related to metabolism. Plasma adiponectin and ADIPOQ are thought to be related to the interaction between obesity, insulin resistance, type 2 diabetes (T2D) and coronary artery disease (CAD) [4].

Meta-analyses have explored the association of ADIPOQ rs2241766 polymorphism with various diseases. One meta-analysis showed that this polymorphism increases the risk of developing T2D (OR = 1.29) [1]. Another indicated a positive correlation between the rs2241766 polymorphism and susceptibility to diabetic kidney disease (DKD) in certain comparisons, especially in Caucasian and African populations as well as in T2DM patients [2]. In a meta-analysis on coronary artery disease (CAD), rs2241766 polymorphism was significantly associated with the susceptibility to CAD in overall population and in different ethnic subgroups [3]. In Mexican adolescents, the ADIPOQ-rs2241766 polymorphism was associated with changes in cholesterol levels [5]. A meta-analysis also found that the ADIPOQ gene rs1501299-T allele was associated with the significant risk of breast cancer [6].

In conclusion, Adipoq is crucial for metabolic homeostasis. Studies on Adipoq gene polymorphisms, especially rs2241766 and rs1501299, have revealed its associations with diseases like T2D, DKD, CAD and breast cancer. These findings from genetic-association studies contribute to understanding the role of Adipoq in disease development and potentially guide future research on disease prevention and treatment.

References:

1. Hamidi, Yeganeh, Saki, Sahar, Afraz, Elham Sadat, Pashapour, Sanaz. 2022. A Meta-analysis of ADIPOQ rs2241766 polymorphism association with type 2 diabetes. In Journal of diabetes and metabolic disorders, 21, 1895-1901. doi:10.1007/s40200-022-01086-0. https://pubmed.ncbi.nlm.nih.gov/36404807/

2. Han, Qiuxia, Geng, Wenjia, Zhang, Dong, Cai, Guangyan, Zhu, Hanyu. 2020. ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease. In Journal of diabetes research, 2020, 5158497. doi:10.1155/2020/5158497. https://pubmed.ncbi.nlm.nih.gov/32685557/

3. Zhang, Xia, Cao, Yan Jun, Zhang, Hong Yu, Cong, Hongliang, Zhang, Jian. 2019. Associations between ADIPOQ polymorphisms and coronary artery disease: a meta-analysis. In BMC cardiovascular disorders, 19, 63. doi:10.1186/s12872-019-1041-3. https://pubmed.ncbi.nlm.nih.gov/30885128/

4. Oliveira, Carolina S V, Giuffrida, Fernando M A, Crispim, Felipe, Saddi-Rosa, Pedro, Reis, André Fernandes. . ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease? In Arquivos brasileiros de endocrinologia e metabologia, 55, 446-54. doi:. https://pubmed.ncbi.nlm.nih.gov/22147092/

5. Reyes Leon-Cachon, Rafael Baltazar, Salinas-Santander, Mauricio Andres, Alejandra Aguilar-Tamez, Daniela, de Jesus Suarez-Valencia, Victor, Morlett-Chavez, Jesus Antonio. 2022. ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents. In Journal of applied biomedicine, 20, 146-153. doi:10.32725/jab.2022.017. https://pubmed.ncbi.nlm.nih.gov/36708720/

6. Peng, Wei-Zhao, Liu, Xin, Li, Chao-Feng, Zhao, Jin. 2023. Genetic alterations in LEP and ADIPOQ genes and risk for breast cancer: a meta-analysis. In Frontiers in oncology, 13, 1125189. doi:10.3389/fonc.2023.1125189. https://pubmed.ncbi.nlm.nih.gov/37274250/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest