Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Impa2em1/Cya
Common Name:
Impa2-KO
Product ID:
S-KO-00880
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Impa2-KO
Strain ID
KOCMP-114663-Impa2-B6J-VA
Gene Name
Impa2
Product ID
S-KO-00880
Gene Alias
2210415D20Rik; IMP 2; IMPase 2
Background
C57BL/6JCya
NCBI ID
114663
Modification
Conventional knockout
Chromosome
18
Phenotype
MGI:2149728
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Impa2em1/Cya mice (Catalog S-KO-00880) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025403
NCBI RefSeq
NM_053261
Target Region
Exon 2
Size of Effective Region
~0.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Inositol monophosphatase 2 (IMPA2) is involved in the MI-PI cycle, promoting the production of IP3. This in turn elevates intracellular Ca2+ concentration, activating pathways such as NFAT1-mediated activation of MYC [1]. IMPA2 is thus important in metabolic-oncogenic crosstalk, playing a significant role in cell-related biological processes. Genetic models, like transgenic mice, can be used to study IMPA2's functions.

In basal-like breast cancer (BLBC), knockdown of IMPA2 expression inhibited tumorigenicity and metastasis in vitro and in vivo. IMPA2 expression was upregulated in BLBC due to copy number amplification, hypomethylation, and MYC-mediated activation, forming a positive feedback loop with MYC to enhance BLBC aggressiveness [1]. In cervical cancer, IMPA2 silencing inhibited cell proliferation, migration, and induced apoptosis, with the IMPA2/AIFM2/p53 pathway potentially being a new mechanism for paclitaxel treatment [2,3]. In metastatic clear cell renal cell carcinoma, IMPA2 downregulation enhanced mTORC1 activity and restrained autophagy initiation, suggesting it could be a biomarker for mTOR inhibitor or autophagy inducer use [4].

In conclusion, IMPA2 is crucial in the MI-PI cycle and intracellular Ca2+ regulation. Model-based research, especially knockdown experiments in various cancer cell lines, has revealed its significant roles in promoting cancer cell aggressiveness in BLBC and cervical cancer, and its impact on mTORC1-autophagy axis in metastatic clear cell renal cell carcinoma. These findings highlight IMPA2 as a potential therapeutic target in these cancer types.

References:

1. Lei, Xingyu, Liao, Ruocen, Chen, Xingyu, Dai, Zhijun, Dong, Chenfang. 2023. IMPA2 promotes basal-like breast cancer aggressiveness by a MYC-mediated positive feedback loop. In Cancer letters, 582, 216527. doi:10.1016/j.canlet.2023.216527. https://pubmed.ncbi.nlm.nih.gov/38048842/

2. Xie, Kexin, Liu, Lei, Wang, Min, Lin, Yingrui, Zhu, Xiaolin. . IMPA2 blocks cervical cancer cell apoptosis and induces paclitaxel resistance through p53-mediated AIFM2 regulation. In Acta biochimica et biophysica Sinica, 55, 623-632. doi:10.3724/abbs.2023069. https://pubmed.ncbi.nlm.nih.gov/37140233/

3. Zhang, Kan, Liu, Lei, Wang, Min, Tan, Shan, Luo, Lingli. 2020. A novel function of IMPA2, plays a tumor-promoting role in cervical cancer. In Cell death & disease, 11, 371. doi:10.1038/s41419-020-2507-z. https://pubmed.ncbi.nlm.nih.gov/32409648/

4. Kuei, Chia-Hao, Lin, Hui-Yu, Lee, Hsun-Hua, Chen, Kuan-Chou, Lin, Yuan-Feng. 2020. IMPA2 Downregulation Enhances mTORC1 Activity and Restrains Autophagy Initiation in Metastatic Clear Cell Renal Cell Carcinoma. In Journal of clinical medicine, 9, . doi:10.3390/jcm9040956. https://pubmed.ncbi.nlm.nih.gov/32235551/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest