Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Acvr1bem1/Cya
Common Name:
Acvr1b-KO
Product ID:
S-KO-00898
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Acvr1b-KO
Strain ID
KOCMP-11479-Acvr1b-B6J-VA
Gene Name
Acvr1b
Product ID
S-KO-00898
Gene Alias
6820432J04; ALK-4; ActR-IB; ActRIB; Acvrlk4; Alk4; SKR2
Background
C57BL/6JCya
NCBI ID
11479
Modification
Conventional knockout
Chromosome
15
Phenotype
MGI:1338944
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Acvr1bem1/Cya mice (Catalog S-KO-00898) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000000544
NCBI RefSeq
NM_007395
Target Region
Exon 2~6
Size of Effective Region
~9.2 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Acvr1b, also known as activin A receptor type 1B or ALK4, is a member of the transforming growth factor-β (TGF-β) superfamily. It mediates the signaling of several TGF-β superfamily ligands and is involved in various biological processes such as cell proliferation, apoptosis, and differentiation. Genetic models, like knockout (KO) and conditional knockout (CKO) mouse models, have been crucial for studying its functions [1,2,3,4,5].

In pancreatic cancer research, Acvr1b loss in mice with Kras mutations in acinar or ductal cells increased the formation of pancreatic intraepithelial neoplasia and IPMN-like lesions, indicating its role in pancreatic precancerous lesion development [1]. In skeletal muscle, combined muscle-specific KO of Tgfbr1 and Acvr1b in mice induced myofibre hypertrophy and accelerated muscle regeneration, showing their synergistic involvement in muscle-related processes [4]. Conditional Acvr1b knockout (Acvr1b(flox/flox); K14-Cre) mice had hair loss abnormalities due to disrupted hair follicle cycling and development, demonstrating a specialized role for Acvr1b in hair-related biology [5].

In conclusion, Acvr1b plays essential roles in multiple biological processes. Studies using KO and CKO mouse models have revealed its significance in pancreatic precancerous lesion formation, muscle function, and hair follicle development. These findings contribute to understanding the molecular mechanisms underlying related diseases and biological functions, potentially providing new insights for disease prevention and treatment [1,4,5].

References:

1. Saeki, Kiyoshi, Wood, Ian S, Wang, Wei Chuan Kevin, Su, Gloria H, Kopp, Janel L. 2024. Acvr1b Loss Increases Formation of Pancreatic Precancerous Lesions From Acinar and Ductal Cells of Origin. In Cellular and molecular gastroenterology and hepatology, 18, 101387. doi:10.1016/j.jcmgh.2024.101387. https://pubmed.ncbi.nlm.nih.gov/39111635/

2. Preechanukul, Anucha, Yimthin, Thatcha, Tandhavanant, Sarunporn, Chantratita, Narisara, Garand, Mathieu. 2023. Abundance of ACVR1B transcript is elevated during septic conditions: Perspectives obtained from a hands-on reductionist investigation. In Frontiers in immunology, 14, 1072732. doi:10.3389/fimmu.2023.1072732. https://pubmed.ncbi.nlm.nih.gov/37020544/

3. Akimoto, Yuki, Fujii, Wataru, Naito, Kunihiko, Sugiura, Koji. 2023. The effect of ACVR1B/TGFBR1/ACVR1C signaling inhibition on oocyte and granulosa cell development during in vitro growth culture. In The Journal of reproduction and development, 69, 270-278. doi:10.1262/jrd.2023-041. https://pubmed.ncbi.nlm.nih.gov/37722883/

4. Hillege, Michèle M G, Shi, Andi, Galli, Ricardo A, Hoogaars, Willem M H, Jaspers, Richard T. 2022. Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration. In eLife, 11, . doi:10.7554/eLife.77610. https://pubmed.ncbi.nlm.nih.gov/35323108/

5. Qiu, Wanglong, Li, Xiaojun, Tang, Hongyan, Owens, David M, Su, Gloria H. 2010. Conditional activin receptor type 1B (Acvr1b) knockout mice reveal hair loss abnormality. In The Journal of investigative dermatology, 131, 1067-76. doi:10.1038/jid.2010.400. https://pubmed.ncbi.nlm.nih.gov/21191412/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest