C57BL/6JCya-Adora2aem1/Cya
Common Name
Adora2a-KO
Product ID
S-KO-00935
Backgroud
C57BL/6JCya
Strain ID
KOCMP-11540-Adora2a-B6J-VA
Status
When using this mouse strain in a publication, please cite “Adora2a-KO Mouse (Catalog S-KO-00935) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Adora2a-KO
Strain ID
KOCMP-11540-Adora2a-B6J-VA
Gene Name
Product ID
S-KO-00935
Gene Alias
A2aR, A2AAR, AA2AR, ARA2A
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000105420
NCBI RefSeq
NM_009630.3
Target Region
Exon 3
Size of Effective Region
~1.4 kb
Overview of Gene Research
ADORA2A, also known as adenosine A2a receptor, is a G protein-coupled receptor. It plays significant roles in various biological processes by regulating multiple pathways. For instance, it can rewire proline metabolism via an ERK/MYC/PYCR cascade, which in turn impacts epigenetic reprogramming [1]. It is also involved in the PI3K/AKT pathway, influencing cell proliferation and apoptosis [2].
In genetically engineered mouse models, ablation of Adora2a inhibits the development and progression of neuroendocrine prostate and lung cancers, and prevents the adenocarcinoma-to-neuroendocrine phenotypic transition. Pharmacological blockade of ADORA2A also represses the growth of these cancers in vivo, indicating its potential as a therapeutic target in neuroendocrine malignancies [1]. In addition, polymorphisms in the ADORA2A gene may influence methotrexate treatment response in rheumatoid arthritis, suggesting its importance in drug-related responses [3].
In conclusion, ADORA2A is involved in key biological processes such as metabolism, cell proliferation, and apoptosis. The use of gene-knockout mouse models has revealed its crucial role in neuroendocrine cancers and its potential influence on drug responses in rheumatoid arthritis, highlighting its significance in disease-related research and potential therapeutic applications.
References:
1. Jing, Na, Zhang, Kai, Chen, Xinyu, Gao, Wei-Qiang, Zhu, Helen He. 2023. ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers. In The Journal of clinical investigation, 133, . doi:10.1172/JCI168670. https://pubmed.ncbi.nlm.nih.gov/38099497/
2. Ran, Longyan, Mou, Xiao, Peng, Zhenglin, Sun, Xingwang, Yin, Tao. 2023. ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma. In Scientific reports, 13, 19477. doi:10.1038/s41598-023-46521-1. https://pubmed.ncbi.nlm.nih.gov/37945707/
3. Kobold, Nadja, Jenko, Barbara, Tomšič, Matija, Dolžan, Vita, Praprotnik, Sonja. . ADORA2A Polymorphisms Influence Methotrexate Adverse Events in Rheumatoid Arthritis. In The Israel Medical Association journal : IMAJ, 21, 333-338. doi:. https://pubmed.ncbi.nlm.nih.gov/31140226/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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