Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Cap1em1/Cya
Common Name:
Cap1-KO
Product ID:
S-KO-01313
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Cap1-KO
Strain ID
KOCMP-12331-Cap1-B6J-VA
Gene Name
Cap1
Product ID
S-KO-01313
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
12331
Modification
Conventional knockout
Chromosome
4
Phenotype
MGI:88262
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cap1em1/Cya mice (Catalog S-KO-01313) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000106255
NCBI RefSeq
NM_007598
Target Region
Exon 3~12
Size of Effective Region
~9.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cap1, also known as Cyclase-Associated Protein 1, is a highly conserved protein with multiple essential functions. It is involved in regulating actin dynamics, which is crucial for various cellular processes such as cell migration, proliferation, and adhesion. Cap1 also participates in cAMP-related signaling pathways, for example, it binds and activates adenylyl cyclase in mammalian cells, modulating cAMP levels and cAMP-dependent proliferation [3]. Additionally, it has been associated with the regulation of innate immune responses through its role in RNA methylation [1]. Genetic models, like gene knockout mouse models, are valuable for studying Cap1's functions.

In lung cancer, knockdown of Cap1 in A549 cells inhibited proliferation and migration, and phosphorylation of specific sites (S308 and S310) in Cap1 promoted lung cancer cell proliferation, migration, and metastasis both in vitro and in vivo [2]. In erythroid differentiation, enforced up-regulation of Cap1 inhibited the formation of contractile actin rings in erythroblasts, preventing their terminal differentiation and enucleation [4]. In colon cancer cells, knockdown of Cap1 led to opposite adhesion phenotypes in different cell lines, and depletion of Cap1 abolished the stimulatory effects of cAMP activators on matrix adhesion, indicating its role in cAMP-Rap1 signaling for adhesion [5]. In the mouse cerebral cortex, inactivation of Cap1 reduced actin monomers in the cytoplasm, promoting nuclear MRTF translocation and MRTF-SRF activation [6].

In conclusion, Cap1 is a key regulator in multiple biological processes. Through model-based research, especially gene knockout mouse models, its role in diseases like cancer, and in biological processes such as erythroid differentiation and cAMP-mediated signaling, has been revealed. These findings contribute to understanding the underlying mechanisms of diseases and may provide potential therapeutic targets.

References:

1. Tsukamoto, Yuta, Igarashi, Manabu, Kato, Hiroki. 2023. Targeting cap1 RNA methyltransferases as an antiviral strategy. In Cell chemical biology, 31, 86-99. doi:10.1016/j.chembiol.2023.11.011. https://pubmed.ncbi.nlm.nih.gov/38091983/

2. Zeng, Jie, Li, Xuan, Liang, Long, Xie, Shuanshuan, Wang, Changhui. 2021. Phosphorylation of CAP1 regulates lung cancer proliferation, migration, and invasion. In Journal of cancer research and clinical oncology, 148, 137-153. doi:10.1007/s00432-021-03819-9. https://pubmed.ncbi.nlm.nih.gov/34636991/

3. Zhang, Xuefeng, Pizzoni, Alejandro, Hong, Kyoungja, Korkhov, Volodymyr, Altschuler, Daniel L. . CAP1 binds and activates adenylyl cyclase in mammalian cells. In Proceedings of the National Academy of Sciences of the United States of America, 118, . doi:10.1073/pnas.2024576118. https://pubmed.ncbi.nlm.nih.gov/34099549/

4. Huang, Xiaoli, Chao, Ruihua, Zhang, Yanyang, Liang, Dongli, Wang, Yuan. 2021. CAP1, a target of miR-144/451, negatively regulates erythroid differentiation and enucleation. In Journal of cellular and molecular medicine, 25, 2377-2389. doi:10.1111/jcmm.16067. https://pubmed.ncbi.nlm.nih.gov/33496386/

5. Ramsey, Auburn, Akana, Lokesh, Miyajima, Erina, Xie, Jennifer Y, Zhou, Guo-Lei. 2023. CAP1 (cyclase-associated protein 1) mediates the cyclic AMP signals that activate Rap1 in stimulating matrix adhesion of colon cancer cells. In Cellular signalling, 104, 110589. doi:10.1016/j.cellsig.2023.110589. https://pubmed.ncbi.nlm.nih.gov/36621727/

6. Khudayberdiev, Sharof, Weiss, Kerstin, Heinze, Anika, Linne, Uwe, Rust, Marco B. 2024. The actin-binding protein CAP1 represses MRTF-SRF-dependent gene expression in mouse cerebral cortex. In Science signaling, 17, eadj0032. doi:10.1126/scisignal.adj0032. https://pubmed.ncbi.nlm.nih.gov/38713765/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest