C57BL/6JCya-Noctem1/Cya
Common Name
Noct-KO
Product ID
S-KO-01380
Backgroud
C57BL/6JCya
Strain ID
KOCMP-12457-Noct-B6J-VA
When using this mouse strain in a publication, please cite “Noct-KO Mouse (Catalog S-KO-01380) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Noct-KO
Strain ID
KOCMP-12457-Noct-B6J-VA
Gene Name
Product ID
S-KO-01380
Gene Alias
Ccr4, Ccrn4l
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000023849
NCBI RefSeq
NM_009834
Target Region
Exon 2~3
Size of Effective Region
~3.8 kb
Overview of Gene Research
Nocturnin (Noct), also known as Ccrn4l, is a protein encoded by the Noct gene. It belongs to the EEP family of proteins with similarity to the CCR4 family of deadenylases. Noct is an output of the circadian clock and helps adjust metabolism according to day-night activity. It is involved in multiple biological processes such as development, adipogenesis, lipid metabolism, inflammation, osteogenesis, and obesity [1]. It also plays a role in maintaining the homeostasis of nicotinamide adenine dinucleotide (NAD) and its phosphorylated form (NADP) by converting NADP(H) into NAD(H) [2].
Mice lacking Noct (Noct KO or Noct-/-) are protected from high-fat diet-induced obesity and hepatic steatosis, suggesting its role in lipid metabolism and obesity-related diseases [1]. A mouse model overexpressing Noct in vivo showed that transgenic male mice had lower fat mass compared to controls, likely through its role as a mediator of mitochondrial function [3].
In conclusion, Noct plays essential roles in metabolism-related biological processes, especially in lipid metabolism and adipocyte function. Studies using Noct KO mouse models have provided valuable insights into its role in obesity-related diseases, highlighting its potential as a target for treating metabolic disorders [1,3].
References:
1. Kulshrestha, Shruti, Devkar, Ranjitsinh. 2023. Circadian control of Nocturnin and its regulatory role in health and disease. In Chronobiology international, 40, 970-981. doi:10.1080/07420528.2023.2231081. https://pubmed.ncbi.nlm.nih.gov/37400970/
2. Chen, Luojun, Xing, Xiaoke, Zhang, Pingfeng, Chen, Lulu, Pei, Huadong. 2023. Homeostatic regulation of NAD(H) and NADP(H) in cells. In Genes & diseases, 11, 101146. doi:10.1016/j.gendis.2023.101146. https://pubmed.ncbi.nlm.nih.gov/38988322/
3. Le, Phuong T, Bornstein, Sheila A, Motyl, Katherine J, Rosen, Clifford J, Guntur, Anyonya R. 2019. A novel mouse model overexpressing Nocturnin results in decreased fat mass in male mice. In Journal of cellular physiology, 234, 20228-20239. doi:10.1002/jcp.28623. https://pubmed.ncbi.nlm.nih.gov/30953371/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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