Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Cdc42em1/Cya
Common Name:
Cdc42-KO
Product ID:
S-KO-01445
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Cdc42-KO
Strain ID
KOCMP-12540-Cdc42-B6J-VA
Gene Name
Cdc42
Product ID
S-KO-01445
Gene Alias
-
Background
C57BL/6JCya
NCBI ID
12540
Modification
Conventional knockout
Chromosome
4
Phenotype
MGI:106211
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cdc42em1/Cya mice (Catalog S-KO-01445) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000051477
NCBI RefSeq
NM_009861
Target Region
Exon 3
Size of Effective Region
~1.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cdc42, a member of the Rho family of small GTPases, is a master regulator of the actin cytoskeleton. It controls crucial cellular processes such as cell motility, polarity, and cell cycle progression. Cdc42 signals downstream of the master regulator Ras and is involved in the Ras-related signaling pathway [2,4,5]. It has been implicated in a wide range of biological functions, including cellular transformation, cell division, invasion, migration, and the formation of invadopodia, filopodia, as well as in maintaining cell polarity [1]. Studies in budding yeast (Saccharomyces cerevisiae) have provided insights into the regulation of Cdc42 for polarized growth, suggesting it has a conserved role in cell polarity establishment across different organisms [3].

Overexpression of Cdc42 is observed in several cancers, where it is linked to poor prognosis and tumour metastasis. In Ras-related cancers, enhanced Cdc42-signaling facilitates Ras-mediated cellular transformation, tumorigenesis, and metastasis. Some Cdc42 inhibitors have shown anticancer effects in Ras-related cancer cell lines derived from breast, colon, lung, and pancreatic cancer [4,5]. Additionally, Cdc42 is involved in the control of gametogenesis in the female reproductive system, playing a key role in the establishment of polarity in oocytes [6]. Aberrant expression of Cdc42, though mutations are rare, has been reported in various tumor types [7].

In conclusion, Cdc42 is essential for multiple biological functions including cell polarity, motility, and cell cycle regulation. Model-based research, such as studies in budding yeast, has provided valuable insights into its function. In the context of diseases, Cdc42's role in cancer, especially Ras-related cancers, and in gametogenesis in the female reproductive system, has been well-documented. Understanding Cdc42's function through these models may offer potential therapeutic strategies for related diseases.

References:

1. Qadir, Muhammad Imran, Parveen, Amna, Ali, Muhammad. 2015. Cdc42: Role in Cancer Management. In Chemical biology & drug design, 86, 432-9. doi:10.1111/cbdd.12556. https://pubmed.ncbi.nlm.nih.gov/25777055/

2. Murphy, Natasha P, Binti Ahmad Mokhtar, Ana Masara, Mott, Helen R, Owen, Darerca. . Molecular subversion of Cdc42 signalling in cancer. In Biochemical Society transactions, 49, 1425-1442. doi:10.1042/BST20200557. https://pubmed.ncbi.nlm.nih.gov/34196668/

3. Miller, Kristi E, Kang, Pil Jung, Park, Hay-Oak. 2020. Regulation of Cdc42 for polarized growth in budding yeast. In Microbial cell (Graz, Austria), 7, 175-189. doi:10.15698/mic2020.07.722. https://pubmed.ncbi.nlm.nih.gov/32656257/

4. Murphy, Natasha P, Mott, Helen R, Owen, Darerca. . Progress in the therapeutic inhibition of Cdc42 signalling. In Biochemical Society transactions, 49, 1443-1456. doi:10.1042/BST20210112. https://pubmed.ncbi.nlm.nih.gov/34100887/

5. Aguilar, Byron J, Zhou, Huchen, Lu, Qun. . Cdc42 Signaling Pathway Inhibition as a Therapeutic Target in Ras- Related Cancers. In Current medicinal chemistry, 24, 3485-3507. doi:10.2174/0929867324666170602082956. https://pubmed.ncbi.nlm.nih.gov/28571533/

6. Mei, Qiaojuan, Li, Huiying, Liu, Yu, Wang, Xiaofei, Xiang, Wenpei. 2021. Advances in the study of CDC42 in the female reproductive system. In Journal of cellular and molecular medicine, 26, 16-24. doi:10.1111/jcmm.17088. https://pubmed.ncbi.nlm.nih.gov/34859585/

7. Arias-Romero, Luis E, Chernoff, Jonathan. 2013. Targeting Cdc42 in cancer. In Expert opinion on therapeutic targets, 17, 1263-73. doi:10.1517/14728222.2013.828037. https://pubmed.ncbi.nlm.nih.gov/23957315/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest