Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Cfhem1/Cya
Common Name:
Cfh-KO
Product ID:
S-KO-01488
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Cfh-KO
Strain ID
KOCMP-12628-Cfh-B6N-VA
Gene Name
Cfh
Product ID
S-KO-01488
Gene Alias
Mud-1; NOM; Sas-1; Sas1
Background
C57BL/6NCya
NCBI ID
12628
Modification
Conventional knockout
Chromosome
1
Phenotype
MGI:88385
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Cfhem1/Cya mice (Catalog S-KO-01488) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000111976
NCBI RefSeq
NM_009888
Target Region
Exon 2~3
Size of Effective Region
~0.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cfh, or Complement factor H, is a key complement inhibitor present as a soluble protein and attached to cell surfaces. It plays a crucial role in complement homeostasis, particularly in inhibiting excessive activation of the complement cascade, especially the alternative pathway. Its significance is underscored by the diverse phenotypes associated with its gene variants [4].

In a mouse model of atherosclerosis, Cfh deficiency limited plaque necrosis in a C3-dependent manner. Deletion of Cfh in monocyte-derived inflammatory macrophages led to uncontrolled cell-autonomous C3 consumption without downstream C5 activation and increased efferocytotic capacity. This shows that Cfh controls intracellular C3 levels of macrophages in a cell-autonomous way, highlighting its importance in the pathogenesis of inflammatory diseases [5]. In early-onset macular degeneration (EOMD), a novel Cfh variant led to loss of Cfh and factor H-like protein 1 (FHL-1) expression, increased local complement activity, and higher MAC deposition, indicating Cfh haploinsufficiency's role in EOMD pathogenesis [1]. In atypical hemolytic uremic syndrome (aHUS), uncommon Cfh-CFHR genomic rearrangements, such as Cfh-CFHR1 hybrid genes, were found in some patients, and those involving Cfh were associated with a poor prognosis but responsiveness to anti-complement therapy [2,3].

In conclusion, Cfh is essential for regulating the complement system. Studies using gene knockout or related models in mice and human patients have revealed its role in diseases like atherosclerosis, EOMD, and aHUS. Understanding Cfh's function through these models helps in elucidating disease mechanisms and potentially developing new treatment strategies for these conditions.

References:

1. Lim, Rayne R, Shirali, Sharlene, Rowlan, Jessica, Neitz, Maureen, Chao, Jennifer R. . CFH Haploinsufficiency and Complement Alterations in Early-Onset Macular Degeneration. In Investigative ophthalmology & visual science, 65, 43. doi:10.1167/iovs.65.4.43. https://pubmed.ncbi.nlm.nih.gov/38683564/

2. Piras, Rossella, Valoti, Elisabetta, Alberti, Marta, Remuzzi, Giuseppe, Noris, Marina. 2023. CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome. In Frontiers in immunology, 13, 1011580. doi:10.3389/fimmu.2022.1011580. https://pubmed.ncbi.nlm.nih.gov/36793547/

3. Sugawara, Yuka, Kato, Hideki, Nagasaki, Masao, Yamamoto, Masayuki, Nangaku, Masaomi. 2023. CFH-CFHR1 hybrid genes in two cases of atypical hemolytic uremic syndrome. In Journal of human genetics, 68, 427-430. doi:10.1038/s10038-023-01129-1. https://pubmed.ncbi.nlm.nih.gov/36755127/

4. Boon, Camiel J F, van de Kar, Nicole C, Klevering, B Jeroen, Daha, Mohamed R, den Hollander, Anneke I. 2009. The spectrum of phenotypes caused by variants in the CFH gene. In Molecular immunology, 46, 1573-94. doi:10.1016/j.molimm.2009.02.013. https://pubmed.ncbi.nlm.nih.gov/19297022/

5. Kiss, Máté G, Papac-Miličević, Nikolina, Porsch, Florentina, Mallat, Ziad, Binder, Christoph J. 2023. Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis. In Immunity, 56, 1809-1824.e10. doi:10.1016/j.immuni.2023.06.026. https://pubmed.ncbi.nlm.nih.gov/37499656/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest