C57BL/6JCya-Campem1/Cya
Common Name:
Camp-KO
Product ID:
S-KO-01558
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Camp-KO
Strain ID
KOCMP-12796-Camp-B6J-VB
Gene Name
Product ID
S-KO-01558
Gene Alias
CAP18; CLP; Cnlp; Cramp; FALL39; MCLP
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Campem1/Cya mice (Catalog S-KO-01558) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000112022
NCBI RefSeq
NM_009921
Target Region
Exon 2~4
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Camp, short for cyclic adenosine monophosphate, is a crucial second messenger that plays pivotal roles in cell signaling. It regulates numerous physiological and pathological processes, mainly through the protein kinase A (PKA) and its downstream effectors like cAMP-responsive element binding protein (CREB). The cAMP-PKA-CREB signaling pathway is involved in various cellular functions such as cell growth, migration, invasion, and metabolism [1].
Aberrant cAMP-PKA signaling is associated with different types of human tumors. In cancer, cAMP-PKA-CREB signaling can have both tumor-suppressive and tumor-promoting roles depending on the tumor types and context. Tumor-associated stromal cells can release cytokines and growth factors that influence cAMP production within the tumor microenvironment (TME). Targeting cAMP signaling in the TME shows therapeutic benefits in cancer, with small-molecule agents that inhibit adenylate cyclase and PKA being able to inhibit tumor growth, and cAMP-elevating agents like forskolin can induce cancer cell death and inhibit cell proliferation in some cancer types [2].
In conclusion, Camp is a key second messenger regulating multiple cellular functions. Its involvement in the cAMP-PKA-CREB signaling pathway is of great significance in tumorigenesis. Understanding the role of Camp in the TME through research can provide new insights for developing effective cancer therapies.
References:
1. Zhang, Hongying, Kong, Qingbin, Wang, Jiao, Jiang, Yangfu, Hua, Hui. 2020. Complex roles of cAMP-PKA-CREB signaling in cancer. In Experimental hematology & oncology, 9, 32. doi:10.1186/s40164-020-00191-1. https://pubmed.ncbi.nlm.nih.gov/33292604/
2. Zhang, Hongying, Liu, Yongliang, Liu, Jieya, Hua, Hui, Jiang, Yangfu. 2024. cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment. In Journal of hematology & oncology, 17, 5. doi:10.1186/s13045-024-01524-x. https://pubmed.ncbi.nlm.nih.gov/38233872/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen