Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Cortem1/Cya
Common Name:
Cort-KO
Product ID:
S-KO-01596
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Cort-KO
Strain ID
KOCMP-12854-Cort-B6J-VA
Gene Name
Cort
Product ID
S-KO-01596
Gene Alias
CST; PCST
Background
C57BL/6JCya
NCBI ID
12854
Modification
Conventional knockout
Chromosome
4
Phenotype
MGI:109538
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cortem1/Cya mice (Catalog S-KO-01596) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000030815
NCBI RefSeq
NM_007745
Target Region
Exon 1~2
Size of Effective Region
~1.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cort, short for cortistatin, is a neuropeptide with a wide-range of biological functions. It is highly related to somatostatin and is involved in multiple regulatory pathways. At the endocrine pancreas, it influences insulin secretion, glucose homeostasis, and insulin resistance [4]. In glioma, CORT is identified as an inhibitor of temozolomide (TMZ) resistance by suppressing the NF-κB-MGMT signaling axis. Decreased CORT expression in glioma tissues is associated with a poorer survival rate, and overexpression of CORT can inhibit glioma cell proliferation, migration, and enhance apoptosis of TMZ-resistant cells [5].

In migratory birds like Gray Catbirds, baseline corticosterone (CORT, the primary glucocorticoid in birds) is thought to underlie transitions between fuel catabolism during flight, fuel deposition during stopover, and the initiation of migratory flight. A U-shaped CORT curve over the course of stopover is predicted, with elevated CORT at arrival responding to poor body condition and elevation before departure driving changes in behavior and body condition [1]. In female Cope's gray treefrogs, CORT and its receptors in the brain are related to mate choosiness. Exogenous CORT can rapidly increase choosiness, and there are changes in the expression of glucocorticoid receptors in the brain following CORT treatment, although the causal relationship is not clear [2]. In salamanders, elevated CORT levels via cutaneous patch lead to significantly less tail regeneration after autotomy, while CORT does not directly affect exploratory behavior but may lead to changes in movement patterns due to delayed regeneration [3].

In conclusion, Cort has diverse functions across different species and biological contexts. In birds, it is related to migratory physiology, in amphibians to mate-choice behavior, in salamanders to autotomy-related processes, and in humans, it has implications in glioma treatment. These findings from various research models help us understand the multiple roles of Cort in different biological processes and disease-related conditions.

References:

1. DeSimone, Joely G, Ramirez, Mariamar Gutierrez, Elowe, Cory R, Breuner, Creagh W, Gerson, Alexander R. 2020. Developing a Stopover-CORT hypothesis: Corticosterone predicts body composition and refueling rate in Gray Catbirds during migratory stopover. In Hormones and behavior, 124, 104776. doi:10.1016/j.yhbeh.2020.104776. https://pubmed.ncbi.nlm.nih.gov/32439349/

2. Rodriguez-Santiago, Mariana, Ruppert, Annika, Gall, Megan D, Bee, Mark A, Baugh, Alexander T. 2024. In your CORT: Corticosterone and its receptors in the brain underlie mate choosiness in female Cope's gray treefrogs (Hyla chrysoscelis). In Hormones and behavior, 159, 105477. doi:10.1016/j.yhbeh.2024.105477. https://pubmed.ncbi.nlm.nih.gov/38245919/

3. Lewis, Jacquelyn L, Sullivan, Aaron M. 2020. Salamander stress and duress: the relationship between CORT, autotomy and regeneration, and exploratory behaviour. In Zoology (Jena, Germany), 139, 125751. doi:10.1016/j.zool.2020.125751. https://pubmed.ncbi.nlm.nih.gov/32070799/

4. Chanclón, Beléen, Martínez-Fuentes, Antonio J, Gracia-Navarro, Francisco. 2012. Role of SST, CORT and ghrelin and its receptors at the endocrine pancreas. In Frontiers in endocrinology, 3, 114. doi:10.3389/fendo.2012.00114. https://pubmed.ncbi.nlm.nih.gov/23162532/

5. He, Zongze, Peng, Bo, Wang, Qi, Jia, Ping, Tang, Jian. 2023. Transcriptomic analysis identifies the neuropeptide cortistatin (CORT) as an inhibitor of temozolomide (TMZ) resistance by suppressing the NF-κB-MGMT signaling axis in human glioma. In Genes & diseases, 11, 100977. doi:10.1016/j.gendis.2023.04.017. https://pubmed.ncbi.nlm.nih.gov/38292193/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest