C57BL/6JCya-Crhr1em1/Cya
Common Name
Crhr1-KO
Product ID
S-KO-01621
Backgroud
C57BL/6JCya
Strain ID
KOCMP-12921-Crhr1-B6J-VA
When using this mouse strain in a publication, please cite “Crhr1-KO Mouse (Catalog S-KO-01621) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Crhr1-KO
Strain ID
KOCMP-12921-Crhr1-B6J-VA
Gene Name
Product ID
S-KO-01621
Gene Alias
CRF-R1alpha, CRF1R, CRFR1, Crhr
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000093925
NCBI RefSeq
NM_007762
Target Region
Exon 4
Size of Effective Region
~2.1 kb
Overview of Gene Research
Crhr1, short for corticotropin releasing hormone receptor 1, is a G protein-coupled receptor. It is crucial in the hypothalamic-pituitary-adrenal (HPA) axis, where corticotropin-releasing hormone (CRH) acts as a neuromodulator to initiate basal and stress-related reactions [1]. CRH-Crhr1 signaling also participates in various extrahypothalamic brain circuits, organizing behavioral and humoral responses to stress, and is involved in multiple physiological and pathophysiological processes.
Genetic studies on Crhr1 have provided significant insights. In mice, the Crhr1 antagonist antalarmin alleviated LPS-induced depression-like behavior, suggesting that Crhr1/nectin3 signaling may play a key role in depression-like behaviors [2]. In another study, stress-induced gut dysbiosis in mice was found to be mediated by the CRH-Crhr1-mitochondria pathway. Antagonizing Crhr1 expression or activating mitochondria respiration could improve gut dysbiosis, indicating the importance of Crhr1 in stress-induced gastrointestinal diseases [3].
In conclusion, Crhr1 is essential for the regulation of stress-related physiological and behavioral responses. Studies using mouse models, especially those targeting Crhr1 through antagonist use or genetic modification, have revealed its significance in diseases such as depression and stress-induced gut dysbiosis. These findings provide potential therapeutic targets for stress-related disorders.
References:
1. Dos Santos Claro, Paula A, Silbermins, Micaela, Inda, Carolina, Silberstein, Susana. 2022. CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling. In Progress in molecular biology and translational science, 196, 229-260. doi:10.1016/bs.pmbts.2022.07.015. https://pubmed.ncbi.nlm.nih.gov/36813360/
2. Sun, Jie, Qiu, Lili, Zhang, Hui, Ju, Lingsha, Yang, Jiaojiao. 2023. CRHR1 antagonist alleviates LPS-induced depression-like behaviour in mice. In BMC psychiatry, 23, 17. doi:10.1186/s12888-023-04519-z. https://pubmed.ncbi.nlm.nih.gov/36624454/
3. Zhang, Yiming, Li, Xiaoang, Lu, Siqi, Pei, Fei, Duan, Liping. 2024. Stress triggers gut dysbiosis via CRH-CRHR1-mitochondria pathway. In NPJ biofilms and microbiomes, 10, 93. doi:10.1038/s41522-024-00571-z. https://pubmed.ncbi.nlm.nih.gov/39349483/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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