C57BL/6JCya-Pcdha11em1/Cya
Common Name
Pcdha11-KO
Product ID
S-KO-01632
Backgroud
C57BL/6JCya
Strain ID
KOCMP-12942-Pcdha11-B6J-VA
When using this mouse strain in a publication, please cite “Pcdha11-KO Mouse (Catalog S-KO-01632) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Pcdha11-KO
Strain ID
KOCMP-12942-Pcdha11-B6J-VA
Gene Name
Product ID
S-KO-01632
Gene Alias
A830022B16Rik, Cnr7, Crnr7
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 18
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000115657
NCBI RefSeq
NM_009960
Target Region
Exon 1
Size of Effective Region
~2.3 kb
Overview of Gene Research
Pcdha11, encoding protocadherin alpha 11, is likely involved in cell-cell adhesion and communication, which are crucial for normal tissue development and function. It may be associated with multiple signaling pathways such as the AKT/mTOR, Wnt/β-catenin, and JAK/STAT pathways, given its impact on cellular functions in cancer cells [1].
In a study on gastric cancer, AmNA-modified anti-PCDHA11 antisense oligonucleotides (ASOs) significantly reduced the proliferation of gastric cancer cells and other solid tumors. Pcdha11-deficient mice demonstrated normal reproductive, organ, and motor functions, yet the ASOs disrupted the AKT/mTOR, Wnt/β-catenin, and JAK/STAT signaling pathways in cancer cells, inhibiting tumor growth in mouse models of peritoneal metastasis, systemic metastasis, and established subcutaneous tumors [1]. In lung squamous cell carcinoma (LUSC), silencing PCDHA11 enhanced the anticancer effects of cisplatin, while its overexpression weakened these effects, suggesting its role in chemoresistance [2].
In summary, Pcdha11 seems to play a role in the proliferation and chemosensitivity of cancer cells, especially in gastric and lung squamous cell carcinomas. Studies using Pcdha11-deficient mouse models and manipulation of PCDHA11 expression in cancer cells have provided insights into its function in tumor-related biological processes, which may contribute to the development of new cancer treatment strategies [1,2].
References:
1. Kanda, Mitsuro, Kasahara, Yuuya, Shimizu, Dai, Kodera, Yasuhiro, Obika, Satoshi. 2024. Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer. In British journal of cancer, 131, 1555-1566. doi:10.1038/s41416-024-02859-5. https://pubmed.ncbi.nlm.nih.gov/39304746/
2. Liang, Yicheng, Liang, Mei, Yan, Tao, Zhou, Boxuan, Gao, Yushun. 2024. miR-185-5p May Modulate the Chemosensitivity of LUSC to Cisplatin via Targeting PCDHA11: Multi-omics Analysis and Experimental Validation. In Biochemical genetics, 63, 1734-1751. doi:10.1007/s10528-024-10795-5. https://pubmed.ncbi.nlm.nih.gov/38613717/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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