C57BL/6NCya-Csf3rem1/Cya
Common Name
Csf3r-KO
Product ID
S-KO-01664
Backgroud
C57BL/6NCya
Strain ID
KOCMP-12986-Csf3r-B6N-VA
When using this mouse strain in a publication, please cite “Csf3r-KO Mouse (Catalog S-KO-01664) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Csf3r-KO
Strain ID
KOCMP-12986-Csf3r-B6N-VA
Gene Name
Product ID
S-KO-01664
Gene Alias
Cd114, Csfgr, G-CSF-R, G-CSFR
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000106162
NCBI RefSeq
NM_007782
Target Region
Exon 7~9
Size of Effective Region
~1.8 kb
Overview of Gene Research
Csf3r, also known as the receptor for colony-stimulating factor 3, is a key component in the granulocyte colony-stimulating factor (G-CSF) signalling pathway. It plays a crucial role in the maturation of neutrophil granulocytes. The G-CSF signalling pathway, in which Csf3r is involved, is essential for haematopoietic processes, especially those related to the production and regulation of neutrophils [3].
Activating mutations in Csf3r are frequently observed in chronic neutrophilic leukemia (CNL) and a subset of atypical chronic myeloid leukemia (aCML). In fact, these mutations were identified in 59% of patients with CNL or aCML, and they lead to preferential downstream kinase signalling through SRC family-TNK2 or JAK kinases, along with differential sensitivity to kinase inhibitors [1]. Additionally, Csf3r mutations are not restricted to CNL. They can also occur in other myeloid neoplasms such as acute myeloid leukemia (AML), chronic myelomonocytic leukemia, and myeloproliferative neoplasm. Co-occurring mutations are often in epigenetic modifier and spliceosome genes, and specific mutations like IDH/RUNX1 and tumor suppressor mutations are frequent in AML but absent in CNL/aCML [2].
In conclusion, Csf3r is vital for neutrophil granulocyte maturation through its role in the G-CSF signalling pathway. The discovery of its activating mutations in CNL, aCML, and other myeloid neoplasms has significant implications for understanding the pathogenesis of these diseases. The study of Csf3r in these contexts helps in identifying potential diagnostic criteria and targeted therapeutic strategies for related haematological malignancies.
References:
1. Maxson, Julia E, Gotlib, Jason, Pollyea, Daniel A, Druker, Brian J, Tyner, Jeffrey W. . Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. In The New England journal of medicine, 368, 1781-90. doi:10.1056/NEJMoa1214514. https://pubmed.ncbi.nlm.nih.gov/23656643/
2. Mohamed, Ahmed, Gao, Juehua, Chen, Yi-Hua, Lu, Xinyan, Chen, Qing. 2024. CSF3R mutated myeloid neoplasms: Beyond chronic neutrophilic leukemia. In Human pathology, 149, 66-74. doi:10.1016/j.humpath.2024.06.008. https://pubmed.ncbi.nlm.nih.gov/38879086/
3. Skokowa, Julia, Dale, David C, Touw, Ivo P, Zeidler, Cornelia, Welte, Karl. 2017. Severe congenital neutropenias. In Nature reviews. Disease primers, 3, 17032. doi:10.1038/nrdp.2017.32. https://pubmed.ncbi.nlm.nih.gov/28593997/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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