C57BL/6JCya-Engem1/Cya
Common Name
Eng-KO
Product ID
S-KO-01881
Backgroud
C57BL/6JCya
Strain ID
KOCMP-13805-Eng-B6J-VA
Status
When using this mouse strain in a publication, please cite “Eng-KO Mouse (Catalog S-KO-01881) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Eng-KO
Strain ID
KOCMP-13805-Eng-B6J-VA
Gene Name
Product ID
S-KO-01881
Gene Alias
Endo, CD105, S-endoglin
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000009705
NCBI RefSeq
NM_007932
Target Region
Exon 2
Size of Effective Region
~0.2 kb
Overview of Gene Research
Eng, also known as Endoglin, is a key regulator involved in immune responses and angiogenesis in liver cancer [1]. It promotes the differentiation of tumor cells into vascular endothelial cells (ECs), playing a crucial role in the formation of tumor vasculature [1].
In liver cancer, high expression of Eng is associated with more aggressive cancer characteristics and worse patient prognosis [1]. Functional experiments, such as Transwell migration assays and tube formation assays with Human Umbilical Vein Endothelial Cells (HUVECs), confirmed that Eng increases the expression of Collagen type Iα1 (COL1A1), thereby promoting angiogenesis in liver cancer [1]. Additionally, HCC patients with elevated Eng levels responded well to sorafenib treatment [1].
In conclusion, Eng is an important biomarker of prognosis in liver cancer. Its role in endothelial cell differentiation and angiogenesis in liver cancer makes it a potential target for identifying liver cancer patients who might benefit from targeted immunotherapies [1].
References:
1. Shi, Shangheng, Zhu, Cunle, Hu, Yue, Zhao, Jinxin, Xu, Qingguo. . ENG is a Biomarker of Prognosis and Angiogenesis in Liver Cancer, and Promotes the Differentiation of Tumor Cells into Vascular ECs. In Frontiers in bioscience (Landmark edition), 29, 315. doi:10.31083/j.fbl2909315. https://pubmed.ncbi.nlm.nih.gov/39344331/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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