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C57BL/6JCya-Fabp3em1/Cya
Common Name:
Fabp3-KO
Product ID:
S-KO-01988
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Fabp3-KO
Strain ID
KOCMP-14077-Fabp3-B6J-VA
Gene Name
Fabp3
Product ID
S-KO-01988
Gene Alias
Fabph-1; Fabph-4; Fabph1; Fabph4; H-FABP; Mdgi
Background
C57BL/6JCya
NCBI ID
14077
Modification
Conventional knockout
Chromosome
4
Phenotype
MGI:95476
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fabp3em1/Cya mice (Catalog S-KO-01988) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000070532
NCBI RefSeq
NM_010174
Target Region
Exon 2~3
Size of Effective Region
~1.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Fabp3, also known as fatty acid binding protein 3, is a member of the cytoplasmic fatty acid binding protein family. It is predominantly expressed in breast, muscle, and heart tissues. Fabp3 is involved in lipid metabolism, where it binds and transports fatty acids, potentially affecting membrane lipid composition and related cellular functions [1,2,3,4,5]. It may be associated with pathways like the PERK-eIF2α pathway, ER stress response, and autophagy, and is of significance in maintaining cellular homeostasis [1,2]. Genetic models, such as gene knockout (KO) mouse models, are valuable for studying its functions.

In sarcopenia, Fabp3 is upregulated in aged skeletal muscles. KO of Fabp3 in aged muscles induces a young-like lipid composition, reduces ER stress, and improves protein synthesis and muscle recovery, indicating its role in regulating muscle homeostasis during aging [1]. In senile osteoporosis, knockdown of Fabp3 alleviates bone loss in aged mice as FABP3 promotes adipogenesis and inhibits osteogenesis of bone marrow mesenchymal stem cells (MSCs), and autophagy receptor OPTN regulates bone-fat balance by clearing FABP3 [2]. In cardiac hypertrophy, Fabp3 deficiency exacerbates metabolic derangement via the PPARα pathway, disrupting metabolic signatures like fatty acid oxidation and ATP production [5].

In conclusion, Fabp3 plays essential roles in lipid-related metabolic processes and cellular homeostasis. Model-based research, especially using KO mouse models, has revealed its significance in diseases such as sarcopenia, senile osteoporosis, and cardiac hypertrophy. Understanding Fabp3 functions provides insights into the underlying mechanisms of these diseases and potential therapeutic targets.

References:

1. Lee, Seung-Min, Lee, Seol Hee, Jung, Youngae, Lee, Kwang-Pyo, Kwon, Ki-Sun. 2020. FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging. In Nature communications, 11, 5661. doi:10.1038/s41467-020-19501-6. https://pubmed.ncbi.nlm.nih.gov/33168829/

2. Liu, Zheng-Zhao, Hong, Chun-Gu, Hu, Wen-Bao, Hu, Rong-Gui, Xie, Hui. 2020. Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3. In Autophagy, 17, 2766-2782. doi:10.1080/15548627.2020.1839286. https://pubmed.ncbi.nlm.nih.gov/33143524/

3. Baru, Ambica, Devi, Chandra, Mukhopadhyay, Tapas, Dogra, Nilambra. 2023. Anti bacterial function of secreted human FABP3. In Biochimica et biophysica acta. General subjects, 1867, 130472. doi:10.1016/j.bbagen.2023.130472. https://pubmed.ncbi.nlm.nih.gov/37788726/

4. Wu, Sifan, Kong, Xiufang, Sun, Ying, Ma, Lili, Jiang, Lindi. . FABP3 overexpression promotes vascular fibrosis in Takayasu's arteritis by enhancing fatty acid oxidation in aorta adventitial fibroblasts. In Rheumatology (Oxford, England), 61, 3071-3081. doi:10.1093/rheumatology/keab788. https://pubmed.ncbi.nlm.nih.gov/34718429/

5. Zhuang, Lingfang, Mao, Ye, Liu, Zizhu, Yan, Xiaoxiang, Chen, Kang. 2021. FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway. In Frontiers in cardiovascular medicine, 8, 722908. doi:10.3389/fcvm.2021.722908. https://pubmed.ncbi.nlm.nih.gov/34458345/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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