Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Fasem1/Cya
Common Name:
Fas-KO
Product ID:
S-KO-02009
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Fas-KO
Strain ID
KOCMP-14102-Fas-B6N-VA
Gene Name
Fas
Product ID
S-KO-02009
Gene Alias
APO1; APT1; CD95; TNFR6; Tnfrsf6; lpr
Background
C57BL/6NCya
NCBI ID
14102
Modification
Conventional knockout
Chromosome
19
Phenotype
MGI:95484
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Fasem1/Cya mice (Catalog S-KO-02009) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025691
NCBI RefSeq
NM_007987
Target Region
Exon 2~4
Size of Effective Region
~9.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Fas, also known as TNFRSF6 (tumor necrosis factor receptor superfamily member 6), is a cell surface receptor that plays a critical role in apoptosis, or programmed cell death. This receptor is a member of the tumor necrosis factor receptor (TNFR) superfamily and is involved in various physiological processes, including immune regulation, development, and the maintenance of homeostasis. Fas ligand (FasL) is the natural ligand of Fas and is responsible for triggering the apoptotic pathway when it binds to Fas. This interaction leads to the formation of a death-inducing signaling complex (DISC), which activates caspases, a family of proteases that are central to the apoptosis process.

Fas and FasL signaling is tightly regulated and dysregulation of this pathway has been implicated in numerous diseases, including autoimmune disorders, neurodegenerative diseases, and cancer. For example, mutations in the Fas gene can lead to autoimmune lymphoproliferative syndrome (ALPS), a disorder characterized by the failure of lymphocytes to undergo apoptosis, resulting in lymphadenopathy and an increased risk of autoimmune diseases[1].

In the context of the provided references, while none of them directly discuss the gene Fas, some of the articles touch on topics that are indirectly related to apoptosis and immune regulation, which are processes Fas is involved in. For instance, the review on idiopathic toe walking[2] discusses the etiology, prevalence, classification, and treatment of this condition, which may involve neurodevelopmental processes that are regulated by apoptosis. Similarly, the article on Achilles tendon rupture[3] discusses the risk factors and injury prevention, which could be relevant to the study of tissue repair and regeneration, where apoptosis plays a role in removing damaged cells.

The article on Bröstrom repair[4] discusses the treatment of chronic ankle instability, which is a condition that could involve inflammation and immune responses, processes in which Fas and FasL signaling are involved. The review on idiopathic toe walking[2] also emphasizes the importance of understanding the causes of the condition and making a differential diagnosis, which is crucial for determining the appropriate therapeutic approach, including those that may involve immune regulation and apoptosis.

In summary, Fas is a crucial gene involved in apoptosis and immune regulation, which are fundamental processes in biology. Although the provided references do not directly discuss the Fas gene, they touch on related topics such as immune regulation, neurodevelopment, and tissue repair, which are processes in which Fas plays a significant role. Further research on Fas and its signaling pathway could provide insights into the development of new therapeutic strategies for various diseases, including autoimmune disorders and cancer.

References:

1. Smith, W Bret. . December FAS Editorial. In Foot & ankle specialist, 12, 502. doi:10.1177/1938640019893403. https://pubmed.ncbi.nlm.nih.gov/31835929/

2. Pomarino, David, Ramírez Llamas, Juliana, Martin, Stephan, Pomarino, Andrea. 2017. Literature Review of Idiopathic Toe Walking: Etiology, Prevalence, Classification, and Treatment. In Foot & ankle specialist, 10, 337-342. doi:10.1177/1938640016687370. https://pubmed.ncbi.nlm.nih.gov/28092971/

3. Hess, Gregory William. 2009. Achilles tendon rupture: a review of etiology, population, anatomy, risk factors, and injury prevention. In Foot & ankle specialist, 3, 29-32. doi:10.1177/1938640009355191. https://pubmed.ncbi.nlm.nih.gov/20400437/

4. Chiou, Daniel, Morris, Brandon, Waryasz, Gregory. 2021. Bröstrom Repair Review. In Foot & ankle specialist, 17, 277-283. doi:10.1177/19386400211053946. https://pubmed.ncbi.nlm.nih.gov/34724848/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest