C57BL/6NCya-Fcnaem1/Cya
Common Name
Fcna-KO
Product ID
S-KO-02026
Backgroud
C57BL/6NCya
Strain ID
KOCMP-14133-Fcna-B6N-VA
When using this mouse strain in a publication, please cite “Fcna-KO Mouse (Catalog S-KO-02026) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Fcna-KO
Strain ID
KOCMP-14133-Fcna-B6N-VA
Gene Name
Product ID
S-KO-02026
Gene Alias
Fcn1
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000028307
NCBI RefSeq
NM_007995
Target Region
Exon 5~7
Size of Effective Region
~0.7 kb
Overview of Gene Research
Fcna, also known as Ficolin A, is a recognition molecule that plays a crucial role in the lectin complement pathway in the innate immune system. It complexes with MBL-associated serine proteases and acts as a soluble pattern recognition molecule [2].
In KO mouse models, Fcna knockout alleviated sepsis-induced severe lung injury in mice by restoring gut Akkermansia to inhibit the S100A4/STAT3 pathway. This was evidenced by increased body weight change, decreased wet/dry weight of lung tissue, reduced inflammatory infiltration, and decreased levels of inflammatory cytokines [1]. Additionally, Fcna knockout attenuated lung inflammation and inhibited neutrophil extracellular traps (NETs) formation in the LPS-induced mouse model, suggesting that Fcna may exacerbate severe lung injury through NETs mediated by Gasdermin D-induced pyroptosis [3]. Fcna-deficient mice were also more susceptible to Streptococcus pneumoniae infection, indicating its importance in host defense against this pathogen [2].
In conclusion, Fcna is essential for innate immunity, especially in defense against certain infections. Through gene knockout studies in mice, it has been shown to play a significant role in the pathogenesis of sepsis-induced severe lung injury and LPS-induced lung injury. These findings provide insights into potential therapeutic targets for treating related diseases.
References:
1. Wu, Xu, Xuan, Weixia, Yang, Xiaoping, Cao, Bin, Jiang, Yongliang. 2023. Ficolin A knockout alleviates sepsis-induced severe lung injury in mice by restoring gut Akkermansia to inhibit S100A4/STAT3 pathway. In International immunopharmacology, 121, 110548. doi:10.1016/j.intimp.2023.110548. https://pubmed.ncbi.nlm.nih.gov/37356123/
2. Endo, Yuichi, Takahashi, Minoru, Iwaki, Daisuke, Schwaeble, Wilhelm J, Fujita, Teizo. 2012. Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection. In Journal of immunology (Baltimore, Md. : 1950), 189, 5860-6. doi:10.4049/jimmunol.1200836. https://pubmed.ncbi.nlm.nih.gov/23150716/
3. Huang, Li, Tan, Xiaowu, Xuan, Weixia, Jiang, Yongliang, Wu, Xu. 2024. Ficolin-A/2 Aggravates Severe Lung Injury through Neutrophil Extracellular Traps Mediated by Gasdermin D-Induced Pyroptosis. In The American journal of pathology, 194, 989-1006. doi:10.1016/j.ajpath.2024.02.011. https://pubmed.ncbi.nlm.nih.gov/38442803/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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