C57BL/6NCya-Fgf15em1/Cya
Common Name
Fgf15-KO
Product ID
S-KO-02039
Backgroud
C57BL/6NCya
Strain ID
KOCMP-14170-Fgf15-B6N-VA
When using this mouse strain in a publication, please cite “Fgf15-KO Mouse (Catalog S-KO-02039) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Fgf15-KO
Strain ID
KOCMP-14170-Fgf15-B6N-VA
Gene Name
Product ID
S-KO-02039
Gene Alias
FGF19, Fgf8a
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000033389
NCBI RefSeq
NM_008003
Target Region
Exon 1~3
Size of Effective Region
~3.6 kb
Overview of Gene Research
Fgf15, the mouse ortholog of human FGF19, is a hormone secreted by ileal enterocytes. It plays a crucial role in the bile acid-FXR-FGF15/19 signaling axis. Bile acids activate the nuclear receptor farnesoid X receptor (FXR) in the ileum, which then regulates the production of Fgf15. Fgf15 travels via the enterohepatic circulation to the liver, where it activates the FGFR4-β-klotho receptor complex, regulating gene expression related to cholesterol, bile acid, and lipid metabolism [1,4].
Intestine-derived Fgf15-knockout (FGF15INT-KO) mice studies showed that gut-derived Fgf15 is important for regulating bile acid and cholesterol metabolism but not essential for energy and glucose balance. FGF15INT-KO mice had increased systemic bile acid levels and decreased cholesterol levels when exposed to an obesogenic diet [2]. Also, Fgf15-null mice did not develop cardiac hypertrophy in response to high-fat diet, isoproterenol, or cold exposure, indicating its role in cardiac hypertrophy development and regulation of fatty acid metabolism in the myocardium [3].
In conclusion, Fgf15 is a key player in the regulation of bile acid, cholesterol, and fatty acid metabolism, as well as cardiac hypertrophy. Gene-knockout mouse models have been instrumental in revealing these functions, providing insights into its potential role in metabolic syndrome and heart-related disease conditions.
References:
1. Katafuchi, Takeshi, Makishima, Makoto. 2022. Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis. In International journal of molecular sciences, 23, . doi:10.3390/ijms23116046. https://pubmed.ncbi.nlm.nih.gov/35682726/
2. Bozadjieva-Kramer, Nadejda, Shin, Jae Hoon, Li, Ziru, Rothberg, Amy E, Seeley, Randy J. 2024. Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance. In JCI insight, 9, . doi:10.1172/jci.insight.174164. https://pubmed.ncbi.nlm.nih.gov/38587078/
3. Morón-Ros, Samantha, Blasco-Roset, Albert, Navarro-Gascon, Artur, Gavaldà-Navarro, Aleix, Planavila, Anna. 2023. A new FGF15/19-mediated gut-to-heart axis controls cardiac hypertrophy. In The Journal of pathology, 261, 335-348. doi:10.1002/path.6193. https://pubmed.ncbi.nlm.nih.gov/37650293/
4. Kliewer, Steven A, Mangelsdorf, David J. 2015. Bile Acids as Hormones: The FXR-FGF15/19 Pathway. In Digestive diseases (Basel, Switzerland), 33, 327-31. doi:10.1159/000371670. https://pubmed.ncbi.nlm.nih.gov/26045265/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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