C57BL/6JCya-Ccn2em1/Cya
Common Name
Ccn2-KO
Product ID
S-KO-02065
Backgroud
C57BL/6JCya
Strain ID
KOCMP-14219-Ccn2-B6J-VA
Status
When using this mouse strain in a publication, please cite “Ccn2-KO Mouse (Catalog S-KO-02065) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ccn2-KO
Strain ID
KOCMP-14219-Ccn2-B6J-VA
Gene Name
Product ID
S-KO-02065
Gene Alias
Ctgf, Hcs24, Fisp12, fisp-12
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000020171
NCBI RefSeq
NM_010217
Target Region
Exon 1~5
Size of Effective Region
~2.8 kb
Overview of Gene Research
Ccn2, also known as connective tissue growth factor (CTGF), is a matricellular protein. It is involved in regulating various biological activities such as cell growth, invasion, and migration, and is associated with pathways like TGF-β, ILK-Syk, and α6β1 integrin receptor-related signaling. Ccn2 is crucial for the harmonized development of tissues like cartilage and bone in the skeletal system [1,3].
A monoallelic variant in CCN2 causes autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass. Osteoblast lineage-specific Ccn2-deficient mice (Ccn2fl/fl;Prx1Cre) recapitulated phenotypes including low bone mass, decreased bone formation, increased bone resorption, and abnormal growth plate formation, highlighting the critical role of CCN2 in osteogenesis [2].
In conclusion, Ccn2 plays essential roles in tissue development, especially in the skeletal system. The Ccn2-deficient mouse model has revealed its significance in osteogenesis and bone-related diseases, providing insights into the understanding of skeletal dysplasia mechanisms and potential therapeutic targets.
References:
1. Ghosh, Priya, Dey, Ankita, Nandi, Suvendu, Das, Subhayan, Mandal, Mahitosh. 2025. CTGF (CCN2): a multifaceted mediator in breast cancer progression and therapeutic targeting. In Cancer metastasis reviews, 44, 32. doi:10.1007/s10555-025-10248-4. https://pubmed.ncbi.nlm.nih.gov/39945880/
2. Li, Shanshan, Shao, Rui, Li, Shufa, Zou, Weiguo, Zhang, Zhenlin. 2024. A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass. In Bone research, 12, 60. doi:10.1038/s41413-024-00364-2. https://pubmed.ncbi.nlm.nih.gov/39414788/
3. Kubota, Satoshi, Takigawa, Masaharu. . Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions. In Clinical science (London, England : 1979), 128, 181-96. doi:10.1042/CS20140264. https://pubmed.ncbi.nlm.nih.gov/25294165/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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