C57BL/6JCya-Fpr1em1/Cya
Common Name
Fpr1-KO
Product ID
S-KO-02109
Backgroud
C57BL/6JCya
Strain ID
KOCMP-14293-Fpr1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Fpr1-KO Mouse (Catalog S-KO-02109) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Fpr1-KO
Strain ID
KOCMP-14293-Fpr1-B6J-VA
Gene Name
Product ID
S-KO-02109
Gene Alias
FPR, LXA4R, fMLF-R
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 17
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000061516
NCBI RefSeq
NM_013521
Target Region
Exon 2
Size of Effective Region
~3.0 kb
Overview of Gene Research
Fpr1, also known as formyl-peptide receptor 1, is a G protein-coupled receptor (GPCR) with a typical seven-transmembrane structure. It can be stimulated by a variety of endogenous or exogenous ligands, such as formyl-methionine-leucyl-phenylalanine (fMLF), and is involved in inflammatory response, immune cell recruitment, and cellular signaling regulation. It participates in key cellular signaling pathways and is of great biological importance in multiple physiological and pathological processes [1].
In Fpr1 -/- mice, dendritic cells show reduced migration in response to chemotherapy-treated colorectal cancer cells, and these mice are more susceptible to chronic ulcerative colitis and colorectal oncogenesis induced by azoxymethane and dextran sodium sulfate, indicating that defective FPR1 signaling favors intestinal tumorigenesis through modulating the innate inflammatory/immune response [2]. In addition, pharmacological inhibition of Fpr1 by cyclosporin H increases intestinal oncogenesis in mice bearing the ApcMin mutation, and this effect can be reversed by the anti-inflammatory drug sulindac [2].
In conclusion, Fpr1 plays a crucial role in regulating inflammatory and immune responses. The study of Fpr1 knockout mouse models has revealed its significant impact on intestinal oncogenesis, suggesting that Fpr1 could be a potential target for treating related diseases. Its functions in inflammation and immunity make it an important gene for understanding the mechanisms of various diseases [1,2].
References:
1. Zhangsun, Ziyin, Dong, Yushu, Tang, Jiayou, Yang, Yang, Zhao, Huadong. 2024. FPR1: A critical gatekeeper of the heart and brain. In Pharmacological research, 202, 107125. doi:10.1016/j.phrs.2024.107125. https://pubmed.ncbi.nlm.nih.gov/38438091/
2. Le Naour, Julie, Montégut, Léa, Pan, Yuhong, Puig, Pierre-Laurent, Kroemer, Guido. 2023. Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis. In Oncoimmunology, 12, 2237354. doi:10.1080/2162402X.2023.2237354. https://pubmed.ncbi.nlm.nih.gov/37492227/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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