C57BL/6NCya-Glp1rem1/Cya
Common Name:
Glp1r-KO
Product ID:
S-KO-02258
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Glp1r-KO
Strain ID
KOCMP-14652-Glp1r-B6N-VA
Gene Name
Product ID
S-KO-02258
Gene Alias
GLP-1R; GLP1Rc
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
17
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Glp1rem1/Cya mice (Catalog S-KO-02258) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000114574
NCBI RefSeq
NM_021332
Target Region
Exon 2~3
Size of Effective Region
~2.4 kb
Detailed Document
Overview of Gene Research
Glp1r, the glucagon-like peptide-1 receptor, is a key component in glucose-related physiological processes. It is activated by glucagon-like peptide-1 (GLP-1), a hormone released from intestinal L cells after nutrient consumption. GLP-1R activation potentiates glucose-induced insulin secretion from pancreatic beta cells, inhibits beta-cell apoptosis, reduces glucagon secretion, delays gastric emptying, promotes satiety, and increases peripheral glucose disposal [2]. These functions link nutrient consumption with blood sugar control, making Glp1r crucial in maintaining metabolic homeostasis.
Polymorphisms in Glp1r are associated with type 2 diabetes. For instance, the G-risk allele at rs761387 was associated with higher total GLP-1, active GLP-1, and a trend toward higher glucose during an oral glucose tolerance test (OGTT), while during a glipizide challenge, it was associated with higher insulin levels. However, other tested variants (rs10305423, rs10305441, rs742762, and rs10305492) were not associated with the tested outcomes. This shows that Glp1r variation can affect GLP-1 levels and potentially the risk of type 2 diabetes through altered incretin signaling [1]. Also, in overweight Chinese type 2 diabetes patients, the variant allele T of rs10305420 was associated with less weight loss and lower HbA1c reduction after 6 months of exenatide (a Glp1r agonist) treatment, indicating its potential as a biomarker for precision medicine in this patient group [3].
In conclusion, Glp1r is essential for regulating glucose metabolism and energy balance. Genetic variations in Glp1r can influence the risk of type 2 diabetes and the response to Glp1r-targeted therapies. Understanding Glp1r through genetic studies, like those examining polymorphisms, provides insights into the molecular mechanisms underlying metabolic diseases and may guide the development of more personalized treatment strategies for type 2 diabetes.
References:
1. Dorsey-Trevino, Edgar G, Kaur, Varinderpal, Mercader, Josep M, Florez, Jose C, Leong, Aaron. . Association of GLP1R Polymorphisms With the Incretin Response. In The Journal of clinical endocrinology and metabolism, 107, 2580-2588. doi:10.1210/clinem/dgac374. https://pubmed.ncbi.nlm.nih.gov/35723666/
2. Donnelly, Dan. . The structure and function of the glucagon-like peptide-1 receptor and its ligands. In British journal of pharmacology, 166, 27-41. doi:10.1111/j.1476-5381.2011.01687.x. https://pubmed.ncbi.nlm.nih.gov/21950636/
3. Yu, Mingjun, Wang, Kaiyu, Liu, Haiming, Cao, Rui. 2019. GLP1R variant is associated with response to exenatide in overweight Chinese Type 2 diabetes patients. In Pharmacogenomics, 20, 273-277. doi:10.2217/pgs-2018-0159. https://pubmed.ncbi.nlm.nih.gov/30883264/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen