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C57BL/6JCya-Lancl1em1/Cya
Common Name:
Lancl1-KO
Product ID:
S-KO-02319
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Lancl1-KO
Strain ID
KOCMP-14768-Lancl1-B6J-VA
Gene Name
Lancl1
Product ID
S-KO-02319
Gene Alias
Gpr69; Gpr69a; p40
Background
C57BL/6JCya
NCBI ID
14768
Modification
Conventional knockout
Chromosome
1
Phenotype
MGI:1336997
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lancl1em1/Cya mice (Catalog S-KO-02319) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000113979
NCBI RefSeq
NM_001190985
Target Region
Exon 1~9
Size of Effective Region
~38.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Lancl1, or Lanthionine synthetase C-like protein 1, is an antioxidant-related protein. It is involved in multiple biological pathways such as those related to oxidative stress regulation. It binds to abscisic acid (ABA) and activates the AMPK/PGC-1α/Sirt1 pathway, influencing glucose transport, mitochondrial respiration, and energy metabolism [3]. Lancl1 is also crucial for maintaining redox homeostasis in various cell types, highlighting its overall biological importance. Genetic models, like gene-knockout (KO) mouse models, are valuable for studying its functions.

In KO mouse models, Lancl1-deficient mice display spermatozoal oxidative damage and impaired male fertility, indicating its role in testicular homeostasis and male fertility regulated by redox balance [4]. In ALS transgenic SOD1G93A mouse models, CNS-specific deletion of Lancl1 leads to neurodegenerative phenotypes, while its overexpression extends lifespan, delays disease onset, and improves motor performance, suggesting it is a positive regulator of AKT activity and a potential therapeutic target in ALS [2]. Prolonged isoflurane anesthesia in animal models reduces Lancl1 expression, causing neurotoxicity, and overexpression of Lancl1 can mitigate this neurotoxic effect, protecting developing neurons [1].

In conclusion, Lancl1 plays essential roles in maintaining redox homeostasis in different biological systems. Model-based research, especially KO/CKO mouse models, has revealed its significance in diseases such as male subfertility, ALS, and anesthesia-induced neurotoxicity. Understanding Lancl1 functions provides potential therapeutic strategies for these conditions.

References:

1. Xie, Wenjia, Xi, Yuqing, Dong, Daoqian, Xia, Tianjiao, Gu, Xiaoping. 2024. LanCL1 protects developing neurons from long-term isoflurane anesthesia-induced neurotoxicity. In Experimental neurology, 381, 114880. doi:10.1016/j.expneurol.2024.114880. https://pubmed.ncbi.nlm.nih.gov/38972370/

2. Tan, Honglin, Chen, Mina, Pang, Dejiang, Worley, Paul F, Xiao, Bo. 2019. LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice. In Cell death and differentiation, 27, 1369-1382. doi:10.1038/s41418-019-0422-6. https://pubmed.ncbi.nlm.nih.gov/31570855/

3. Spinelli, Sonia, Begani, Giulia, Guida, Lucrezia, Zocchi, Elena, Sturla, Laura. 2021. LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway. In Molecular metabolism, 53, 101263. doi:10.1016/j.molmet.2021.101263. https://pubmed.ncbi.nlm.nih.gov/34098144/

4. Huang, Chao, Yang, Chengcheng, Pang, Dejiang, Xiao, Bo, Chen, Zhengli. 2022. Animal models of male subfertility targeted on LanCL1-regulated spermatogenic redox homeostasis. In Lab animal, 51, 133-145. doi:10.1038/s41684-022-00961-w. https://pubmed.ncbi.nlm.nih.gov/35469022/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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