C57BL/6NCya-Mst1em1/Cya
Common Name
Mst1-KO
Product ID
S-KO-02447
Backgroud
C57BL/6NCya
Strain ID
KOCMP-15235-Mst1-B6N-VA
When using this mouse strain in a publication, please cite “Mst1-KO Mouse (Catalog S-KO-02447) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Mst1-KO
Strain ID
KOCMP-15235-Mst1-B6N-VA
Gene Name
Product ID
S-KO-02447
Gene Alias
D3F15S2h, D9H3F15S2, DNF15S2h, Hgfl
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000035211
NCBI RefSeq
NM_008243
Target Region
Exon 2~8
Size of Effective Region
~1.4 kb
Overview of Gene Research
Mst1, also known as mammalian sterile 20-like kinase 1, belongs to the serine/threonine protein kinase superfamily and is a key component of the mechanosensitive Hippo pathway. It plays vital roles in inflammation, immunity, and various physiological and pathological processes. In inflammation, it generally aggravates inflammatory injury via pathways like MST1-JNK, MST1-mROS, MST1-Foxo3, and NF-κB, along with regulatory factors such as TNF-α, MIEF1, and LPS [1]. In immunity, it balances immune activation and tolerance through regulating multiple pathways and molecules [1].
In an atherosclerosis model, mice with EC-specific Mst1 deficiency (Mst1iECKOApoE-/-) showed that inhibition of the MST1-Cx43 axis drives oscillatory shear stress-induced endothelial dysfunction and atherosclerosis, suggesting MST1 as a potential therapeutic target [2]. In non-alcoholic fatty liver disease (NAFLD), genetic ablation of Mst1 in mice attenuated HFD-mediated hepatic injury, indicating Mst1's role in disrupting Parkin-related mitophagy in NAFLD [3].
In conclusion, Mst1 is a crucial regulator in multiple biological processes. Studies using gene knockout (KO) or conditional knockout (CKO) mouse models have revealed its significance in diseases such as atherosclerosis and NAFLD, providing potential therapeutic directions for these conditions.
References:
1. Li, Tongfen, Wen, Yiqiong, Lu, Qiongfen, Zheng, Yuanyuan, Sun, Shibo. 2023. MST1/2 in inflammation and immunity. In Cell adhesion & migration, 17, 1-15. doi:10.1080/19336918.2023.2276616. https://pubmed.ncbi.nlm.nih.gov/37909712/
2. Quan, Meixi, Lv, Huizhen, Liu, Zening, Zhu, Yi, Ai, Ding. 2022. MST1 Suppresses Disturbed Flow Induced Atherosclerosis. In Circulation research, 131, 748-764. doi:10.1161/CIRCRESAHA.122.321322. https://pubmed.ncbi.nlm.nih.gov/36164986/
3. Zhou, Tao, Chang, Ling, Luo, Yi, Zhou, Ying, Zhang, Jianjun. 2019. Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy. In Redox biology, 21, 101120. doi:10.1016/j.redox.2019.101120. https://pubmed.ncbi.nlm.nih.gov/30708325/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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