Hspa1b, a member of the Heat Shock Protein Family A, is a heat shock protein that plays crucial roles in regulating cellular responses. It is involved in various cellular functions such as protein folding, assembly, and degradation, and is associated with pathways like the MAPK signaling pathway [3]. Heat shock proteins are generally important for cells to cope with stress conditions. Genetic models can be valuable for studying Hspa1b to understand its functions in normal and disease states.

Hspa1b has been associated with multiple disease conditions. In type 2 diabetes and its complications, Hspa1b is among the proteins associated with most microvascular complications [1]. In tophi patients, Hspa1b is over-expressed in the blood and may serve as a potential diagnostic marker [2]. In acute myocardial infarction, Hspa1b is identified as one of the hub genes related to ferroptosis and hypoxia [3]. In schizophrenia, Hspa1b gene polymorphisms may be involved in susceptibility to the disease and its clinical presentation in a sex-dependent manner, and may play a role in suicidal behavior [4]. In colon cancer, high expression of Hspa1b is related to unfavorable survival [5]. In hepatocellular carcinoma, Hspa1b is highly expressed in ILC2s in late-stage HCC, and targeting its downstream effector may suppress tumor growth [6]. The gene variant rs2763979 of Hspa1b might have prognostic utility as a genetic marker for asthma [7].

In conclusion, Hspa1b is an important gene involved in protein-related cellular functions and is associated with a variety of diseases including diabetes, tophi, acute myocardial infarction, schizophrenia, colon cancer, hepatocellular carcinoma, and asthma. Although no KO/CKO mouse models are mentioned in the references, the findings from human-based studies provide insights into its role in these disease conditions, highlighting its potential as a biomarker or therapeutic target.

References:

1. Yuan, Shuai, Xu, Fengzhe, Li, Xue, Mantzoros, Christos S, Larsson, Susanna C. 2023. Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses. In Cell reports. Medicine, 4, 101174. doi:10.1016/j.xcrm.2023.101174. https://pubmed.ncbi.nlm.nih.gov/37652020/

2. Li, Yang, Shan, Chen, Yang, Bo, Wang, Hu. . Up-regulation of HSPA1A and HSPA1B in the blood of tophi patients and its clinical significance. In Acta biochimica Polonica, 69, 781-785. doi:10.18388/abp.2020_6066. https://pubmed.ncbi.nlm.nih.gov/36515646/

3. Liu, Kai, Chen, Shaoxi, Lu, Ruoyi. . Identification of important genes related to ferroptosis and hypoxia in acute myocardial infarction based on WGCNA. In Bioengineered, 12, 7950-7963. doi:10.1080/21655979.2021.1984004. https://pubmed.ncbi.nlm.nih.gov/34565282/

4. Kowalczyk, Malgorzata, Kucia, Krzysztof, Owczarek, Aleksander, Choreza, Piotr, Kowalski, Jan. 2019. Association of HSPA1B Polymorphisms with Paranoid Schizophrenia in a Polish Population. In Neuromolecular medicine, 22, 159-169. doi:10.1007/s12017-019-08575-1. https://pubmed.ncbi.nlm.nih.gov/31642026/

5. Guan, Yufeng, Zhu, Xianjun, Liang, Junjie, Huang, Shan, Pan, Xiaofen. 2021. Upregulation of HSPA1A/HSPA1B/HSPA7 and Downregulation of HSPA9 Were Related to Poor Survival in Colon Cancer. In Frontiers in oncology, 11, 749673. doi:10.3389/fonc.2021.749673. https://pubmed.ncbi.nlm.nih.gov/34765552/

6. He, Yuanlin, Luo, Jiajing, Zhang, Guannan, Dai, Juncheng, Chen, Yun. 2022. Single-cell profiling of human CD127+ innate lymphoid cells reveals diverse immune phenotypes in hepatocellular carcinoma. In Hepatology (Baltimore, Md.), 76, 1013-1029. doi:10.1002/hep.32444. https://pubmed.ncbi.nlm.nih.gov/35243668/

7. Faisal, Salwa, Abdelaal, Sherouk, Jeraiby, Mohammed A, Fawzy, Manal S, Ibrahim, Ahmed. 2022. Diagnostic and Prognostic Risk Assessment of Heat Shock Protein HSPA1B rs2763979 Gene Variant in Asthma. In Genes, 13, . doi:10.3390/genes13122391. https://pubmed.ncbi.nlm.nih.gov/36553658/