C57BL/6JCya-Il13ra1em1/Cya
Common Name
Il13ra1-KO
Product ID
S-KO-02622
Backgroud
C57BL/6JCya
Strain ID
KOCMP-16164-Il13ra1-B6J-VA
When using this mouse strain in a publication, please cite “Il13ra1-KO Mouse (Catalog S-KO-02622) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Il13ra1-KO
Strain ID
KOCMP-16164-Il13ra1-B6J-VA
Gene Name
Product ID
S-KO-02622
Gene Alias
NR4, Il13ra, CD213a1, IL-13r[a], IL-13R-alpha-1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000033418
NCBI RefSeq
NM_133990
Target Region
Exon 2
Size of Effective Region
~0.1 kb
Overview of Gene Research
Il13ra1, the interleukin 13 receptor subunit alpha-1, is a key component of the receptor complexes for cytokines IL-4 and IL-13. These cytokines regulate various aspects of allergic inflammation, such as lymphocyte, myeloid cell, and non-hematopoietic cell responses. IL-4 and IL-13 can induce alternative macrophage activation through the receptor complex containing Il13ra1 [1].
In a study on eosinophilic esophagitis (EoE), Il13ra1 -/- mice and in vivo IL-13 antibody-based neutralization experiments blocked antigen-induced esophageal epithelial and lamina propria thickening, basal cell proliferation, eosinophilia, and tissue remodeling. Targeted deletion of Il13ra1 in esophageal epithelial cells also protected mice from experimental EoE, demonstrating a definitive role for IL-13 signaling via Il13ra1 in EoE [3]. In bullous pemphigoid, the IL13-IL13RA1 ligand-receptor pair was identified as the most significant mediator of immune-stromal crosstalk [2].
In conclusion, Il13ra1 is crucial for cytokine-mediated immune responses, especially those related to type 2 inflammation. The use of Il13ra1 knockout mouse models has revealed its role in diseases like EoE and bullous pemphigoid, highlighting its potential as a therapeutic target in such type 2 inflammatory disease conditions.
References:
1. Junttila, Ilkka S. 2018. Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes. In Frontiers in immunology, 9, 888. doi:10.3389/fimmu.2018.00888. https://pubmed.ncbi.nlm.nih.gov/29930549/
2. Liu, Tingting, Wang, Zhenzhen, Xue, Xiaotong, Liu, Hong, Zhang, Furen. 2024. Single-cell transcriptomics analysis of bullous pemphigoid unveils immune-stromal crosstalk in type 2 inflammatory disease. In Nature communications, 15, 5949. doi:10.1038/s41467-024-50283-3. https://pubmed.ncbi.nlm.nih.gov/39009587/
3. Avlas, Shmulik, Shani, Guy, Rhone, Natalie, Rothenberg, Marc E, Munitz, Ariel. 2022. Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis. In Allergy, 78, 464-476. doi:10.1111/all.15510. https://pubmed.ncbi.nlm.nih.gov/36070083/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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