Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Kcnmb1em1/Cya
Common Name:
Kcnmb1-KO
Product ID:
S-KO-02767
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Kcnmb1-KO
Strain ID
KOCMP-16533-Kcnmb1-B6J-VA
Gene Name
Kcnmb1
Product ID
S-KO-02767
Gene Alias
BKbeta1
Background
C57BL/6JCya
NCBI ID
16533
Modification
Conventional knockout
Chromosome
11
Phenotype
MGI:1334203
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Kcnmb1em1/Cya mice (Catalog S-KO-02767) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000020362
NCBI RefSeq
NM_031169
Target Region
Exon 2~3
Size of Effective Region
~2.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
KCNMB1, encoding the β1 subunit of the large-conductance calcium-activated potassium (BK) channel, is crucial for regulating BK channel function. The BK channels are involved in various physiological processes, such as controlling smooth muscle contraction, neurotransmitter release, and maintaining vascular flexibility [3,4,6].

In a meta-analysis, the dominant model of KCNMB1 E65K polymorphism was significantly associated with essential hypertension risk in Asian population, suggesting its potential role in hypertension-related genetic susceptibility [1]. In the context of pulmonary fibrosis, fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) show increased KCNMB1 expression, which corresponds to enhanced BK channel activity. Knockdown of KCNMB1 attenuates the ability of fibroblasts to differentiate into myofibroblasts, highlighting its role in fibrotic disorders [2]. In atherosclerotic blood vessels, 7-ketocholesterol, an atherogenic factor, down-regulates KCNMB1 through the aryl hydrocarbon receptor (AhR) pathway, potentially contributing to vascular rigidity and hypertension [4]. Mice lacking Kcnmb1 (Kcnmb1-/-) are hypertensive, volume expanded, and have reduced urinary K and Na clearances. The hypertension in these mice is mainly due to aldosteronism resulting from renal potassium retention and hyperkalemia, indicating a renal origin of the hypertension phenotype [5].

In conclusion, KCNMB1 plays essential roles in multiple biological processes and disease conditions. Studies using gene-knockout mouse models, like the Kcnmb1-/-mice, have revealed its significant contributions to hypertension, pulmonary fibrosis, and atherosclerosis-related pathophysiological mechanisms. These findings provide valuable insights into understanding the underlying molecular mechanisms of these diseases and may potentially guide the development of novel therapeutic strategies.

References:

1. Zhancheng, Wang, Wenhui, Ji, Yun, Jiang, Yan, Shen, Jin, Li. . The dominant models of KCNJ11 E23K and KCNMB1 E65K are associated with essential hypertension (EH) in Asian: Evidence from a meta-analysis. In Medicine, 98, e15828. doi:10.1097/MD.0000000000015828. https://pubmed.ncbi.nlm.nih.gov/31169684/

2. Scruggs, Anne M, Grabauskas, Gintautas, Huang, Steven K. . The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation and Pulmonary Fibrosis. In American journal of respiratory cell and molecular biology, 62, 191-203. doi:10.1165/rcmb.2019-0163OC. https://pubmed.ncbi.nlm.nih.gov/31486669/

3. Bukiya, Anna N, Leo, M Dennis, Jaggar, Jonathan H, Dopico, Alex M. 2021. Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma. In The Journal of biological chemistry, 296, 100381. doi:10.1016/j.jbc.2021.100381. https://pubmed.ncbi.nlm.nih.gov/33556372/

4. Son, Yonghae, Chun, Wonjoo, Ahn, Yong-Tae, Lee, Chu, An, Won G. 2015. 7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels. In Biochemical and biophysical research communications, 457, 324-7. doi:10.1016/j.bbrc.2014.12.109. https://pubmed.ncbi.nlm.nih.gov/25576871/

5. Grimm, P Richard, Irsik, Debra L, Settles, Deann C, Holtzclaw, J David, Sansom, Steven C. 2009. Hypertension of Kcnmb1-/- is linked to deficient K secretion and aldosteronism. In Proceedings of the National Academy of Sciences of the United States of America, 106, 11800-5. doi:10.1073/pnas.0904635106. https://pubmed.ncbi.nlm.nih.gov/19556540/

6. Toro, B, Cox, N, Wilson, R J, Toro, L, Zarei, M M. 2006. KCNMB1 regulates surface expression of a voltage and Ca2+-activated K+ channel via endocytic trafficking signals. In Neuroscience, 142, 661-9. doi:. https://pubmed.ncbi.nlm.nih.gov/16908104/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest