C57BL/6JCya-Ltaem1/Cya
Common Name:
Lta-KO
Product ID:
S-KO-02921
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Lta-KO
Strain ID
KOCMP-16992-Lta-B6J-VA
Gene Name
Product ID
S-KO-02921
Gene Alias
LT; LT-[a]; LT-alpha; LT[a]; LTalpha; Ltx; TNF-beta; TNFSF1; Tnfb; Tnfsf1b; Tnlg1e; hlb382
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
17
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ltaem1/Cya mice (Catalog S-KO-02921) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025266
NCBI RefSeq
NM_010735
Target Region
Exon 2~4
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Lta, or Lymphotoxin-α, is a gene encoding a protein that has implications in various biological processes and diseases. It is associated with the regulation of the immune response and has been linked to pathways related to inflammation and cancer development [1,2]. Lta gene polymorphisms may influence an individual's susceptibility to certain diseases, making it an important gene for genetic studies.
In terms of disease associations, specific Lta gene polymorphisms, such as rs2239704, are inversely associated with the risk of cancer, while rs1041981 polymorphism shows a negative association with cancer risk in Asians. Additionally, rs909253 polymorphism is a risk factor for HCC in the Caucasian population [1]. Moreover, a haplotype within the Lta gene (CTTAC haploblock) is associated with protection towards periodontitis in Italian adults [2].
In conclusion, Lta is a gene with significant implications in disease susceptibility. Studies on Lta gene polymorphisms have provided insights into how genetic variations can influence an individual's risk of developing cancer and periodontal disease. Understanding the role of Lta through genetic models can offer valuable information for disease prevention and treatment strategies related to these conditions.
References:
1. Li, Jingdong, Wang, Yaxuan, Chang, Xueliang, Han, Zhenwei. . The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis. In Bioscience reports, 40, . doi:10.1042/BSR20192320. https://pubmed.ncbi.nlm.nih.gov/32420584/
2. Zupin, Luisa, Moura Rodrigues, Ronald, Navarra, Chiara Ottavia, Crovella, Sergio, Robino, Antonietta. 2018. Association of LTA gene haploblock with periodontal disease in Italian adults. In Journal of periodontal research, 54, 128-133. doi:10.1111/jre.12609. https://pubmed.ncbi.nlm.nih.gov/30284722/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen