C57BL/6NCya-Grin3bem1/Cya
Common Name
Grin3b-KO
Product ID
S-KO-02940
Backgroud
C57BL/6NCya
Strain ID
KOCMP-170483-Grin3b-B6N-VA
When using this mouse strain in a publication, please cite “Grin3b-KO Mouse (Catalog S-KO-02940) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Grin3b-KO
Strain ID
KOCMP-170483-Grin3b-B6N-VA
Gene Name
Product ID
S-KO-02940
Gene Alias
NR3B, GluN3B
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000045085
NCBI RefSeq
NM_130455
Target Region
Exon 1~4
Size of Effective Region
~5.1 kb
Overview of Gene Research
Grin3b, which encodes the GluN3B subunit of the N-methyl-D-aspartate (NMDA) receptor, is a crucial gene. The NMDA receptor is a glutamate-gated ionotropic cation channel, and many forms of synaptic plasticity rely on calcium ion influx through it. Thus, Grin3b is involved in important neural signal-transduction pathways and is of great significance for normal brain function [1].
In a family with a strong history of psychotic disorders, a frameshift mutation (rs10666583) in the Grin3B gene was found in all family members with a psychotic disorder but not in healthy relatives. This mutation degrades the S1/S2 glycine-binding domain of the GluN3B subunit, affecting the channel pore's calcium-ion permeability and potentially causing impaired NMDA receptor function, suggesting it could be a risk factor for psychotic disorders [1]. Additionally, in a transcriptome-wide association study, GRIN3B blood mRNA levels were associated with chronic vs. resilient post-trauma symptom trajectories, and genetic variants regulating its mRNA blood expression levels were identified, indicating its potential role in the manifestation of PTSD [2].
In conclusion, Grin3b is essential for the normal function of the NMDA receptor and synaptic plasticity. Studies on genetic mutations in families with psychotic disorders and post-trauma symptom trajectories in individuals suggest that Grin3b may play a role in the pathogenesis of psychotic disorders and PTSD, providing valuable insights into these complex neuropsychiatric conditions.
References:
1. Hornig, Tobias, Grüning, Björn, Kundu, Kousik, Biber, Knut, Normann, Claus. 2017. GRIN3B missense mutation as an inherited risk factor for schizophrenia: whole-exome sequencing in a family with a familiar history of psychotic disorders. In Genetics research, 99, e1. doi:10.1017/S0016672316000148. https://pubmed.ncbi.nlm.nih.gov/28132660/
2. Lori, Adriana, Schultebraucks, Katharina, Galatzer-Levy, Isaac, Wingo, Aliza P, Ressler, Kerry J. 2021. Transcriptome-wide association study of post-trauma symptom trajectories identified GRIN3B as a potential biomarker for PTSD development. In Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 46, 1811-1820. doi:10.1038/s41386-021-01073-8. https://pubmed.ncbi.nlm.nih.gov/34188182/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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