C57BL/6JCya-Mc3rem1/Cya
Common Name
Mc3r-KO
Product ID
S-KO-03150
Backgroud
C57BL/6JCya
Strain ID
KOCMP-17201-Mc3r-B6J-VA
Status
When using this mouse strain in a publication, please cite “Mc3r-KO Mouse (Catalog S-KO-03150) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Mc3r-KO
Strain ID
KOCMP-17201-Mc3r-B6J-VA
Gene Name
Product ID
S-KO-03150
Gene Alias
MC3-R
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000038532
NCBI RefSeq
NM_008561
Target Region
Exon 1
Size of Effective Region
~2.6 kb
Overview of Gene Research
Mc3r, the melanocortin 3 receptor, is a G-protein coupled receptor. It is mainly known as a regulator of the appetite/hunger balance mechanisms. It is also involved in the central melanocortin system, which is crucial for energy homeostasis [1]. Genetic models, such as gene knockout (KO) mouse models, have been instrumental in studying its functions.
Mice lacking Mc3r have shown delayed sexual maturation, insensitivity of reproductive cycle length to nutritional perturbation, reduced linear growth, lean mass, and circulating levels of IGF1 [2]. In humans, carriers of loss-of-function mutations in MC3R also have a later onset of puberty. Functionally damaging variants in MC3R are overrepresented in individuals with constitutional delay of growth and puberty (CDGP) [3]. Inhibition of MC3R in mice improves the dose-responsiveness to anorexigenic agents like Glucagon-like peptide 1 (GLP1) agonists [4].
In conclusion, Mc3r plays essential roles in regulating sexual maturation, linear growth, lean mass accrual, and appetite. KO mouse models have been key in revealing its role in CDGP. These findings enhance our understanding of the biological processes regulated by Mc3r and its potential implications in related disease conditions.
References:
1. Yanik, Tulin, Durhan, Seyda Tugce. 2022. Specific Functions of Melanocortin 3 Receptor (MC3R). In Journal of clinical research in pediatric endocrinology, 15, 1-6. doi:10.4274/jcrpe.galenos.2022.2022-5-21. https://pubmed.ncbi.nlm.nih.gov/36053086/
2. Lam, B Y H, Williamson, A, Finer, S, Yeo, G S, O'Rahilly, S. 2021. MC3R links nutritional state to childhood growth and the timing of puberty. In Nature, 599, 436-441. doi:10.1038/s41586-021-04088-9. https://pubmed.ncbi.nlm.nih.gov/34732894/
3. Duckett, Katie, Williamson, Alice, Kincaid, John W R, Ong, Ken K, O'Rahilly, Stephen. . Prevalence of Deleterious Variants in MC3R in Patients With Constitutional Delay of Growth and Puberty. In The Journal of clinical endocrinology and metabolism, 108, e1580-e1587. doi:10.1210/clinem/dgad373. https://pubmed.ncbi.nlm.nih.gov/37339320/
4. Dahir, Naima S, Gui, Yijun, Wu, Yanan, Mapp, Anna K, Cone, Roger D. 2023. Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.12.05.570114. https://pubmed.ncbi.nlm.nih.gov/38106197/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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