Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Pias2em1/Cya
Common Name:
Pias2-KO
Product ID:
S-KO-03198
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Pias2-KO
Strain ID
KOCMP-17344-Pias2-B6J-VA
Gene Name
Pias2
Product ID
S-KO-03198
Gene Alias
ARIP3; DIP; Dib; Miz1; PIASxalpha; PIASxalpha6; PIASxb; PIASxbeta; SIZ2
Background
C57BL/6JCya
NCBI ID
17344
Modification
Conventional knockout
Chromosome
18
Phenotype
MGI:1096566
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Pias2em1/Cya mice (Catalog S-KO-03198) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000114777
NCBI RefSeq
NM_008602.4
Target Region
Exon 2
Size of Effective Region
~0.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
PIAS2, also known as protein inhibitor of activated STAT 2, is a key modulator in multiple biological processes. It is involved in signal transduction pathways, particularly those regulated by transcription factors such as NF-κB, IRF3, and JAK/STAT [2]. PIAS2 has SUMO E3 ligase activity which allows it to modify proteins through SUMOylation, influencing various cellular functions [3,5].

In the context of diseases, in sporadic Parkinson disease dementia (sPDD), elevated PIAS2 was associated with defective neuronal IFNβ-IFNAR signaling. Overexpressing PIAS2 in mouse brains caused motor and cognitive impairments, intraneuronal phosphorylated α-synuclein accumulation, and dopaminergic neuron loss. Conversely, PIAS2 knockdown in Ifnb-/- mice rescued the clinicopathological manifestations of PDD by restoring mitochondrial homeostasis and relevant signaling pathways [1]. In anaplastic carcinomas, depletion of the PIAS2β isoform specifically inhibited the growth of cancer cell lines and patient primary cultures in vitro and orthotopic patient-derived xenografts in vivo, as PIAS2β is required for proper mitotic spindle and centrosome assembly [4].

In summary, PIAS2 plays a significant role in regulating cellular functions through its involvement in signal transduction and SUMOylation. Research using mouse models has revealed its contribution to neurodegenerative diseases like sPDD and cancer, highlighting its potential as a therapeutic target for these conditions.

References:

1. Magalhaes, Joana, Tresse, Emilie, Ejlerskov, Patrick, Gasser, Thomas, Issazadeh-Navikas, Shohreh. 2021. PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia. In Molecular psychiatry, 26, 6083-6099. doi:10.1038/s41380-021-01207-w. https://pubmed.ncbi.nlm.nih.gov/34234281/

2. Zu, Shaopo, Xue, Qian, He, Zhuoliang, Jiao, Peirong, Liao, Ming. 2020. Duck PIAS2 negatively regulates RIG-I mediated IFN-β production by interacting with IRF7. In Developmental and comparative immunology, 108, 103664. doi:10.1016/j.dci.2020.103664. https://pubmed.ncbi.nlm.nih.gov/32151676/

3. Zu, Shaopo, Xue, Qian, He, Zhuoliang, Jiao, Peirong, Liao, Ming. 2020. Duck PIAS2 Promotes H5N1 Avian Influenza Virus Replication Through Its SUMO E3 Ligase Activity. In Frontiers in microbiology, 11, 1246. doi:10.3389/fmicb.2020.01246. https://pubmed.ncbi.nlm.nih.gov/32595623/

4. Rodrigues, Joana S, Chenlo, Miguel, Bravo, Susana B, Cameselle-Teijeiro, José Manuel, Alvarez, Clara V. 2024. dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe. In Nature communications, 15, 3736. doi:10.1038/s41467-024-47751-1. https://pubmed.ncbi.nlm.nih.gov/38744818/

5. Du, Junfeng, Du, Yujia, Chen, Lang, Liu, Hongwei. 2023. IL-17 promotes melanoma through TRAF2 as a scaffold protein recruiting PIAS2 and ELAVL1 to induce EPHA5. In Biochimica et biophysica acta. Molecular cell research, 1870, 119547. doi:10.1016/j.bbamcr.2023.119547. https://pubmed.ncbi.nlm.nih.gov/37481078/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest