Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Msnem1/Cya
Common Name:
Msn-KO
Product ID:
S-KO-03255
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Msn-KO
Strain ID
KOCMP-17698-Msn-B6N-VA
Gene Name
Msn
Product ID
S-KO-03255
Gene Alias
-
Background
C57BL/6NCya
NCBI ID
17698
Modification
Conventional knockout
Chromosome
X
Phenotype
MGI:97167
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Msnem1/Cya mice (Catalog S-KO-03255) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000117399
NCBI RefSeq
NM_010833
Target Region
Exon 4~13
Size of Effective Region
~14.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Msn, short for Moesin, is a member of the ezrin-radixin-moesin family. It connects the cell membrane to the actin-based cytoskeleton, regulating cell morphology. It is involved in multiple biological processes and is associated with pathways such as the β-catenin-RUNX2 axis and PKC-mediated CREB signaling pathway, playing important roles in cell proliferation, adhesion, migration, and invasion [1,2,3].

In patients, novel mutations in the Msn gene can lead to immunodeficiency. A 10-year-old boy with a novel hemizygous mutation (c.68 A > G, p.N23S) presented with recurrent fever, oral ulcers, dermatomyositis-like symptoms, EBV infection, and later developed nasal-type NK/T-cell lymphoma. His immunological phenotype included persistent decreases in T and B lymphocyte counts [1]. Two brothers with a hemizygous missense mutation (c.511C > T:p.R171W) had repeated lung infections, significantly decreased lymphocyte and neutrophil levels, and bronchiectasis and emphysema [4]. In cancer research, higher Msn expression in CRC tissues is associated with poor patient survival rates. Msn silencing inhibits CRC cell proliferation, adhesion, migration, and invasion in vitro, while overexpression accelerates these processes via the β-catenin-RUNX2 axis [2]. In TNBC, Msn is significantly overexpressed and promotes cell proliferation, invasion, and tumor growth through phosphorylation-mediated nuclear localization and activation of the CREB signaling pathway [3].

In conclusion, Msn is crucial in regulating cell-cytoskeleton interactions and associated biological functions. Studies on Msn gene-mutated patients have revealed its significance in immunodeficiency-related diseases. In cancer, Msn's role in promoting disease progression through specific signaling pathways makes it a potential therapeutic target for CRC and TNBC.

References:

1. Sun, Bijun, Liu, Luyao, Han, Lingli, Wang, Xiaochuan, Sun, Jinqiao. 2024. Novel Mutation in the Moesin (MSN) Gene Leads to Immunodeficiency with Epstein-Barr Virus (EBV) Infection and Dermatomyositis-Like Symptoms. In Journal of clinical immunology, 44, 155. doi:10.1007/s10875-024-01755-0. https://pubmed.ncbi.nlm.nih.gov/38922539/

2. Huang, Chien-Yu, Wei, Po-Li, Batzorig, Uyanga, Lee, Cheng-Chin, Chang, Yu-Jia. 2023. Identification of Moesin (MSN) as a Potential Therapeutic Target for Colorectal Cancer via the β-Catenin-RUNX2 Axis. In International journal of molecular sciences, 24, . doi:10.3390/ijms241310951. https://pubmed.ncbi.nlm.nih.gov/37446127/

3. Qin, Yuanyuan, Chen, Weilong, Jiang, Guojuan, Huang, Shenglin, Liu, Suling. 2020. Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer. In Science advances, 6, eaaw9960. doi:10.1126/sciadv.aaw9960. https://pubmed.ncbi.nlm.nih.gov/32128390/

4. Li, Muquan, Luo, Shuanghong, Zhuo, Zhiqiang, Shu, Min. 2023. Two cases of pediatric primary immunodeficiency caused by a familial moesin(MSN)gene mutation. In Clinical immunology (Orlando, Fla.), 258, 109858. doi:10.1016/j.clim.2023.109858. https://pubmed.ncbi.nlm.nih.gov/38052292/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest