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C57BL/6NCya-Tesminem1/Cya
Common Name:
Tesmin-KO
Product ID:
S-KO-03275
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Tesmin-KO
Strain ID
KOCMP-17771-Tesmin-B6N-VA
Gene Name
Tesmin
Product ID
S-KO-03275
Gene Alias
Mtl5
Background
C57BL/6NCya
NCBI ID
17771
Modification
Conventional knockout
Chromosome
19
Phenotype
MGI:1340029
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Tesminem1/Cya mice (Catalog S-KO-03275) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025840
NCBI RefSeq
NM_001039657
Target Region
Exon 2~5
Size of Effective Region
~5.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Tesmin, also known as Metallothionein-like 5 (Mtl5), is a gene encoding a cysteine-rich protein. It has been linked to functions in spermatogenesis and oogenesis and may be involved in cell-cycle-related pathways. Its study using genetic models like knockout mice has been crucial for understanding its biological importance [1,3].

In gene knockout studies, Tesmin-deficient male mice are infertile due to arrested spermatogenesis at the pachytene stage, while female mice remain fertile. The long transcript form, Tesmin-L, can rescue this infertility, indicating its critical role in meiotic completion during spermatogenesis [1]. In addition, in vitro experiments on the NCI-H1703 cell line showed that silencing MTL5 (Tesmin) mRNA and Tesmin led to downregulation of MCM5 and MCM7 expression levels and a decrease in the number of cells in the G2 phase, suggesting its role in non-small cell lung cancer (NSCLC) cell proliferation [2].

In conclusion, Tesmin is essential for spermatogenesis in male mice, with Tesmin-L being critical for meiotic completion. Its study through KO mouse models has also provided insights into its potential role in NSCLC carcinogenesis, highlighting its importance in understanding male fertility and certain cancer-related processes.

References:

1. Oji, Asami, Isotani, Ayako, Fujihara, Yoshitaka, Oura, Seiya, Ikawa, Masahito. . Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice†. In Biology of reproduction, 102, 975-983. doi:10.1093/biolre/ioaa002. https://pubmed.ncbi.nlm.nih.gov/31916570/

2. Grzegrzolka, Jedrzej, Olbromski, Mateusz, Gomulkiewicz, Agnieszka, Podhorska-Okolow, Marzena, Dziegiel, Piotr. 2020. Role of tesmin expression in non-small cell lung cancer. In Oncology letters, 21, 48. doi:10.3892/ol.2020.12309. https://pubmed.ncbi.nlm.nih.gov/33281959/

3. Cao, Lijun, Zhang, Lin, Liu, Siyu, Wang, Xue. 2024. Clinical Significance and Functional Insights of Tesmin in Hepatocellular Carcinoma. In Genetics research, 2024, 3058875. doi:10.1155/2024/3058875. https://pubmed.ncbi.nlm.nih.gov/38283987/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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