C57BL/6JCya-Muc1em1/Cya
Common Name
Muc1-KO
Product ID
S-KO-03282
Backgroud
C57BL/6JCya
Strain ID
KOCMP-17829-Muc1-B6J-VA
When using this mouse strain in a publication, please cite “Muc1-KO Mouse (Catalog S-KO-03282) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Muc1-KO
Strain ID
KOCMP-17829-Muc1-B6J-VA
Gene Name
Product ID
S-KO-03282
Gene Alias
CD227, EMA, Muc-1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000041142
NCBI RefSeq
NM_013605
Target Region
Exon 2~6
Size of Effective Region
~2.2 kb
Overview of Gene Research
MUC1, also known as CD227, is a highly glycosylated transmembrane mucin expressed on the luminal surface of epithelial cells. It protects epithelial cells from extreme factors and has anti-adhesive, immunosuppressive properties, and is involved in cell signaling [1,4]. In normal cells, it functions in the reproductive tract and immune system and protects against infections [4].
In cancer cells, MUC1 expression is upregulated, and its protein structure, glycosylation level, and spatial distribution are altered. It participates in regulating several signaling pathways, influencing tumor cell metabolism, apoptosis, epithelial-mesenchymal transition, and distant metastasis. For example, in neuroendocrine prostate cancer, MUC1-C (encoded by MUC1) suppresses the AR axis, induces pluripotency factors, and activates neural transcription factors, promoting the cancer stem cell state, and targeting MUC1-C inhibits self-renewal and tumorigenicity [3]. In breast cancer, its overexpression and aberrant glycosylation make it an ideal target for immunotherapy [2].
In conclusion, MUC1 has essential functions in normal biological processes but is also significantly involved in cancer progression. Studies on MUC1, especially through models like those related to neuroendocrine prostate cancer, have revealed its role in tumor-associated signaling pathways, providing potential targets for cancer treatment [3].
References:
1. Qing, Liangliang, Li, Qingchao, Dong, Zhilong. 2022. MUC1: An emerging target in cancer treatment and diagnosis. In Bulletin du cancer, 109, 1202-1216. doi:10.1016/j.bulcan.2022.08.001. https://pubmed.ncbi.nlm.nih.gov/36184332/
2. Li, Zhifeng, Yang, Dazhuang, Guo, Ting, Lin, Mei. 2022. Advances in MUC1-Mediated Breast Cancer Immunotherapy. In Biomolecules, 12, . doi:10.3390/biom12070952. https://pubmed.ncbi.nlm.nih.gov/35883508/
3. Kufe, Donald. 2023. Dependence on MUC1-C in Progression of Neuroendocrine Prostate Cancer. In International journal of molecular sciences, 24, . doi:10.3390/ijms24043719. https://pubmed.ncbi.nlm.nih.gov/36835130/
4. Apostolopoulos, Vasso, Stojanovska, Lily, Gargosky, Sharron E. 2015. MUC1 (CD227): a multi-tasked molecule. In Cellular and molecular life sciences : CMLS, 72, 4475-500. doi:10.1007/s00018-015-2014-z. https://pubmed.ncbi.nlm.nih.gov/26294353/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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