C57BL/6JCya-Neurl1aem1/Cya
Common Name:
Neurl1a-KO
Product ID:
S-KO-03352
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Neurl1a-KO
Strain ID
KOCMP-18011-Neurl1a-B6J-VA
Gene Name
Product ID
S-KO-03352
Gene Alias
2410129E16Rik; Neu1; Neur1; Neurl; Neurl1; Nlz; Rnf67
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
19
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Neurl1aem1/Cya mice (Catalog S-KO-03352) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000111808
NCBI RefSeq
NM_021360
Target Region
Exon 2~6
Size of Effective Region
~17.6 kb
Detailed Document
Overview of Gene Research
Neurl1a, though no common aliases are provided in the given reference, is involved in a process related to protein ubiquitination. It appears to play a role in the regulation of cannabinoid receptor 1 (CB1) ubiquitination, which is associated with the endocannabinoid system pathway. This system is crucial in various physiological processes such as memory, mood, and pain perception, indicating the biological importance of Neurl1a [1].
In a study on ovariectomized mice, high-throughput sequencing showed that in 17β-estradiol (E2)-treated mice 3 months after ovariectomy (OVXLT), miR-221-5p decreased, leading to upregulation of Neurl1a/b, which promoted CB1 ubiquitination. This impairment was not seen in mice 1 week after ovariectomy (OVXST). Blood samples from postmenopausal women also indicated a decrease in miR-221-5p. Rescuing miR-221-5p or using a CB1 agonist could reverse the impairment of fear extinction in E2-treated OVXLT mice [1].
In conclusion, Neurl1a is involved in the ubiquitination of CB1, which is relevant to the "window of opportunity" for estrogen treatment in post-menopausal conditions. The study in ovariectomized mice, a form of in vivo research model, reveals that Neurl1a may play a role in the impaired memory-related processes associated with long-term post-menopause, potentially providing insights into improving hormone therapy for long-term menopausal women [1].
References:
1. Zhang, Kun, Yang, Qi, Yang, Le, Liu, Shui-Bing, Zhao, Ming-Gao. 2019. CB1 agonism prolongs therapeutic window for hormone replacement in ovariectomized mice. In The Journal of clinical investigation, 129, 2333-2350. doi:10.1172/JCI123689. https://pubmed.ncbi.nlm.nih.gov/31063987/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen