C57BL/6JCya-Nmbrem1/Cya
Common Name
Nmbr-KO
Product ID
S-KO-03386
Backgroud
C57BL/6JCya
Strain ID
KOCMP-18101-Nmbr-B6J-VA
When using this mouse strain in a publication, please cite “Nmbr-KO Mouse (Catalog S-KO-03386) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Nmbr-KO
Strain ID
KOCMP-18101-Nmbr-B6J-VA
Gene Name
Product ID
S-KO-03386
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000020015
NCBI RefSeq
NM_008703
Target Region
Exon 2
Size of Effective Region
~0.3 kb
Overview of Gene Research
Nmbr, the neuromedin B receptor, is a G-protein-coupled receptor. It binds to neuromedin B (NMB), a bombesin-related peptide, and is involved in various physiological processes. These include the regulation of exocrine and endocrine secretions, smooth muscle contraction, and it has been implicated in itch transmission pathways [2,4].
In itch-related functional studies, Nmbr knockout (KO) mice showed normal scratching behavior in response to intradermal injection of pruritogens. However, mice lacking both Nmbr and Grpr (double KO, DKO) had significant deficits in histaminergic itch, suggesting that Nmbr and Grpr can compensate for each other to maintain normal histamine-evoked itch [3]. Also, B-type natriuretic peptide (BNP) was found to facilitate NMB-encoded histaminergic itch via NPRC-NMBR crosstalk, indicating a role of Nmbr in the modulation of itch signals [1].
In conclusion, Nmbr plays a role in the transmission and modulation of histaminergic itch. The use of Nmbr KO mouse models has been crucial in uncovering these functions, highlighting the importance of Nmbr in the complex network of itch-related signaling pathways.
References:
1. Meng, Qing-Tao, Liu, Xian-Yu, Liu, Xue-Ting, Tao, Ailin, Chen, Zhou-Feng. 2021. BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk. In eLife, 10, . doi:10.7554/eLife.71689. https://pubmed.ncbi.nlm.nih.gov/34919054/
2. González, Nieves, Nakagawa, Tomoo, Mantey, Samuel A, Katsuno, Tatsuro, Jensen, Robert T. 2009. Molecular basis for the selectivity of the mammalian bombesin peptide, neuromedin B, for its receptor. In The Journal of pharmacology and experimental therapeutics, 331, 265-76. doi:10.1124/jpet.109.154245. https://pubmed.ncbi.nlm.nih.gov/19628633/
3. Zhao, Zhong-Qiu, Wan, Li, Liu, Xian-Yu, Li, Yun-Qing, Chen, Zhou-Feng. . Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission. In The Journal of neuroscience : the official journal of the Society for Neuroscience, 34, 12402-14. doi:10.1523/JNEUROSCI.1709-14.2014. https://pubmed.ncbi.nlm.nih.gov/25209280/
4. Ohki-Hamazaki, H. . Neuromedin B. In Progress in neurobiology, 62, 297-312. doi:. https://pubmed.ncbi.nlm.nih.gov/10840151/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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