C57BL/6JCya-Or6a2em1/Cya
Common Name
Or6a2-KO
Product ID
S-KO-03481
Backgroud
C57BL/6JCya
Strain ID
KOCMP-18317-Or6a2-B6J-VA
When using this mouse strain in a publication, please cite “Or6a2-KO Mouse (Catalog S-KO-03481) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Or6a2-KO
Strain ID
KOCMP-18317-Or6a2-B6J-VA
Gene Name
Product ID
S-KO-03481
Gene Alias
I7, MOR103-15, Olfr2, Olfr41
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000094109
NCBI RefSeq
NM_010983
Target Region
Exon 2
Size of Effective Region
~2.7 kb
Overview of Gene Research
OR6A2, the human ortholog of mouse Olfr2, is an olfactory receptor belonging to the G-protein-coupled receptor family. It plays a role in detecting the compound octanal. When activated by octanal, it is involved in the NLRP3 inflammasome-dependent interleukin-1β (IL-1β) secretion pathway, which has implications in inflammatory responses [1].
In mouse models, genetic targeting of Olfr2 (the mouse ortholog of OR6A2) significantly reduced atherosclerotic plaques. Boosting octanal levels exacerbated atherosclerosis, indicating that activation of Olfr2/OR6A2 promotes the development of atherosclerosis [1]. This shows that in vivo, the function of OR6A2 (through its mouse ortholog) can influence the progression of atherosclerotic disease.
In conclusion, OR6A2 is an olfactory receptor that activates the NLRP3-IL-1β pathway upon octanal binding. Mouse models with genetic targeting of its ortholog Olfr2 have revealed its role in promoting atherosclerosis, suggesting that inhibiting OR6A2 could be a potential strategy for preventing and treating this disease [1].
References:
1. Orecchioni, Marco, Kobiyama, Kouji, Winkels, Holger, Hazen, Stanley L, Ley, Klaus. 2022. Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production. In Science (New York, N.Y.), 375, 214-221. doi:10.1126/science.abg3067. https://pubmed.ncbi.nlm.nih.gov/35025664/
2. Orecchioni, Marco, Matsunami, Hiroaki, Ley, Klaus. 2022. Olfactory receptors in macrophages and inflammation. In Frontiers in immunology, 13, 1029244. doi:10.3389/fimmu.2022.1029244. https://pubmed.ncbi.nlm.nih.gov/36311776/
3. Wang, Congcong, Andreasson, Katrin I. 2022. Odorant receptors in macrophages: potential targets for atherosclerosis. In Trends in immunology, 43, 262-264. doi:10.1016/j.it.2022.02.006. https://pubmed.ncbi.nlm.nih.gov/35283015/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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