C57BL/6JCya-Osmem1/Cya
Common Name
Osm-KO
Product ID
S-KO-03530
Backgroud
C57BL/6JCya
Strain ID
KOCMP-18413-Osm-B6J-VA
When using this mouse strain in a publication, please cite “Osm-KO Mouse (Catalog S-KO-03530) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Osm-KO
Strain ID
KOCMP-18413-Osm-B6J-VA
Gene Name
Product ID
S-KO-03530
Gene Alias
OncoM
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000075221
NCBI RefSeq
NM_001013365
Target Region
Exon 1~3
Size of Effective Region
~3.1 kb
Overview of Gene Research
Oncostatin M (OSM), a member of the interleukin-6 (IL-6) family of cytokines, is involved in diverse inflammatory responses such as wound healing, liver regeneration, and bone remodeling. It binds the shared receptor gp130, recruits either OSMRβ or LIFRβ, and activates signaling pathways like JAK/STAT, MAPK, JNK, and PI3K/AKT [1,2].
In cancer-associated cachexia, OSM overexpression in mice causes muscle wasting, while muscle-specific deletion of the OSM receptor (OSMR) and neutralization of circulating OSM preserve muscle mass and function in tumor-bearing mice, indicating OSM/OSMR signaling drives muscle atrophy [3]. In pressure-overload induced cardiac hypertrophy, OSMR-knockout (OSMR-KO) mice show aggravated cardiac hypertrophy, fibrotic remodelling, and cardiac dysfunction. The loss of OSMR activates OSM/LIFR/STAT3 signalling and promotes a pro-resolving macrophage phenotype that exacerbates inflammation and impairs cardiac repair [4].
In conclusion, OSM is a pleiotropic cytokine with a significant role in multiple biological processes and diseases. Gene knockout models, like the OSMR-KO mouse, have revealed its functions in muscle wasting associated with cancer and in cardiac hypertrophy, highlighting its potential as a therapeutic target in these disease areas.
References:
1. Wolf, Cody L, Pruett, Clyde, Lighter, Darren, Jorcyk, Cheryl L. 2023. The clinical relevance of OSM in inflammatory diseases: a comprehensive review. In Frontiers in immunology, 14, 1239732. doi:10.3389/fimmu.2023.1239732. https://pubmed.ncbi.nlm.nih.gov/37841259/
2. Lantieri, Francesca, Bachetti, Tiziana. 2022. OSM/OSMR and Interleukin 6 Family Cytokines in Physiological and Pathological Condition. In International journal of molecular sciences, 23, . doi:10.3390/ijms231911096. https://pubmed.ncbi.nlm.nih.gov/36232392/
3. Domaniku-Waraich, Aylin, Agca, Samet, Toledo, Batu, Kashgari, Aynur Erkin, Kir, Serkan. 2024. Oncostatin M signaling drives cancer-associated skeletal muscle wasting. In Cell reports. Medicine, 5, 101498. doi:10.1016/j.xcrm.2024.101498. https://pubmed.ncbi.nlm.nih.gov/38569555/
4. Feng, Yizhou, Yuan, Yuan, Xia, Hongxia, Shen, Difei, Tang, Qizhu. 2023. OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling. In Journal of translational medicine, 21, 290. doi:10.1186/s12967-023-04163-x. https://pubmed.ncbi.nlm.nih.gov/37120549/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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