C57BL/6JCya-Pcxem1/Cya
Common Name
Pcx-KO
Product ID
S-KO-03580
Backgroud
C57BL/6JCya
Strain ID
KOCMP-18563-Pcx-B6J-VA
When using this mouse strain in a publication, please cite “Pcx-KO Mouse (Catalog S-KO-03580) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Pcx-KO
Strain ID
KOCMP-18563-Pcx-B6J-VA
Gene Name
Product ID
S-KO-03580
Gene Alias
Pc, Pcb
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000068004
NCBI RefSeq
NM_001162946
Target Region
Exon 3~9
Size of Effective Region
~5.2 kb
Overview of Gene Research
Pcx, the gene encoding pyruvate carboxylase, is a catalytic enzyme within mitochondria. Pyruvate carboxylase is intricately linked with mitochondrial damage and metabolism, playing a role in various metabolic pathways [1].
In a study on renal fibrosis, renal proximal tubule-specific Pcx gene knockout mice (PcxcKO) showed significant interstitial fibrosis compared to control mice, with heightened expression of extracellular matrix molecules. Mechanistically, PC deficiency reduces its interaction with sulfide:quinone oxidoreductase (SQOR), leading to mitochondrial morphological and functional disruption, increased mtDNA release, activation of the cGAS-STING pathway, elevated glycolysis levels, and ultimately promoting renal fibrosis [1].
In conclusion, Pcx plays a crucial role in maintaining mitochondrial function and metabolism. The PcxcKO mouse model has revealed its significance in renal fibrosis, providing a novel theoretical foundation and potential therapeutic targets for understanding the pathogenesis and treatment of this disease.
References:
1. Huang, Hao, Han, Yuanyuan, Zhang, Yan, Tao, Lijian, Peng, Zhangzhe. 2025. Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING-Mediated Glycolysis. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 12, e2408753. doi:10.1002/advs.202408753. https://pubmed.ncbi.nlm.nih.gov/39836535/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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