C57BL/6JCya-Pnliprp1em1/Cya
Common Name
Pnliprp1-KO
Product ID
S-KO-03727
Backgroud
C57BL/6JCya
Strain ID
KOCMP-18946-Pnliprp1-B6J-VA
When using this mouse strain in a publication, please cite “Pnliprp1-KO Mouse (Catalog S-KO-03727) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Pnliprp1-KO
Strain ID
KOCMP-18946-Pnliprp1-B6J-VA
Gene Name
Product ID
S-KO-03727
Gene Alias
Plrp1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000048644
NCBI RefSeq
NM_018874
Target Region
Exon 3~9
Size of Effective Region
~7.1 kb
Overview of Gene Research
Pnliprp1, pancreatic lipase-related protein 1, is a gene with a role in fat digestion as a triglyceride lipase inhibitor [2,3]. It may be involved in lipid metabolism-related pathways. Its biological importance lies in its potential impact on metabolic processes and exocrine pancreatic function [1]. Genetic models, such as gene knockout (KO) mouse models, can be valuable for studying its function.
In human studies, PNLIPRP1 null variants are associated with elevated glycemia and LDL cholesterol. Mendelian randomization indicates that type 2 diabetes (T2D) causes PNLIPRP1 hypermethylation, which in turn causes an increase in LDL cholesterol. In rat exocrine cell analyses, Pnliprp1 knockdown induces acinar-to-ductal metaplasia, a pre-pancreatic cancer state, and increases cholesterol levels, which can be reversed by statin [1]. Also, in the context of diet, its loss in some species is associated with low-fat intake, suggesting a beneficial role in fat-poor ecological niches [2].
In conclusion, Pnliprp1 is crucial in lipid metabolism and exocrine pancreatic function. Findings from genetic-model-based research, like the association between its null variants and metabolic changes, highlight its importance in T2D and cholesterol metabolism, as well as its potential implications in pancreatic diseases [1].
References:
1. Maurin, Lucas, Marselli, Lorella, Boissel, Mathilde, Froguel, Philippe, Khamis, Amna. . PNLIPRP1 Hypermethylation in Exocrine Pancreas Links Type 2 Diabetes and Cholesterol Metabolism. In Diabetes, 73, 1908-1918. doi:10.2337/db24-0215. https://pubmed.ncbi.nlm.nih.gov/39137110/
2. Wagner, Franziska, Ruf, Irina, Lehmann, Thomas, Stefen, Clara, Stuckas, Heiko. 2022. Reconstruction of evolutionary changes in fat and toxin consumption reveals associations with gene losses in mammals: A case study for the lipase inhibitor PNLIPRP1 and the xenobiotic receptor NR1I3. In Journal of evolutionary biology, 35, 225-239. doi:10.1111/jeb.13970. https://pubmed.ncbi.nlm.nih.gov/34882899/
3. Hecker, Nikolai, Sharma, Virag, Hiller, Michael. 2019. Convergent gene losses illuminate metabolic and physiological changes in herbivores and carnivores. In Proceedings of the National Academy of Sciences of the United States of America, 116, 3036-3041. doi:10.1073/pnas.1818504116. https://pubmed.ncbi.nlm.nih.gov/30718421/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.