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C57BL/6NCya-Ptprfem1/Cya
Common Name:
Ptprf-KO
Product ID:
S-KO-03926
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Ptprf-KO
Strain ID
KOCMP-19268-Ptprf-B6N-VA
Gene Name
Ptprf
Product ID
S-KO-03926
Gene Alias
LAR; LARS; RPTP-LAR
Background
C57BL/6NCya
NCBI ID
19268
Modification
Conventional knockout
Chromosome
4
Phenotype
MGI:102695
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Ptprfem1/Cya mice (Catalog S-KO-03926) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000049074
NCBI RefSeq
NM_011213
Target Region
Exon 4~22
Size of Effective Region
~52.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ptprf, Protein Tyrosine Phosphatase Receptor Type F, is an important phosphatase involved in regulating cell growth, differentiation, and oncogenic transformation [2]. It localizes to adherens junctions and may be involved in the regulation of epithelial cell-cell contacts, peptide growth factor signaling, and the canonical Wnt pathway [6].

In cancer research, in lung adenocarcinoma, Fascin Actin-Bundling Protein 1 (FSCN1) promotes the secretion of cytokines in tumor cells, which in turn increase PTPRF expression in macrophages, leading to M2 polarization of macrophages and tumor progression. Knocking down PTPRF in macrophages reduces lung adenocarcinoma proliferative and metastatic capacity [1]. In gastric adenocarcinoma, lower PTPRF levels are associated with advanced tumor TNM stages and poorer overall survival. Overexpressing PTPRF inhibits tumor migration and invasion by deactivating the ERK1/2 signaling pathway [2]. In breast cancer, PPARγ inhibits tumor cell proliferation by upregulating PTPRF expression [3]. In gliomas, lncRNA TCONS_00004099-derived microRNA promotes glioma malignant behaviors through targeting PTPRF [4]. In non-small-cell lung cancer, PTPRF expression is prognostic for shorter overall survival but predictive of improved survival with erlotinib [5]. In gall bladder carcinoma, downregulation of PTPRF is noted during the expression of miR-145 [7].

In conclusion, Ptprf plays a crucial role in various biological processes and disease conditions, especially in cancer development and progression. Studies on Ptprf using gene-related models have provided valuable insights into its functions in different diseases, which may help in developing new therapeutic strategies.

References:

1. Huang, Yiwei, Shan, Guangyao, Yi, Yanjun, Jiang, Wei, Zhan, Cheng. 2022. FSCN1 induced PTPRF-dependent tumor microenvironment inflammatory reprogramming promotes lung adenocarcinoma progression via regulating macrophagic glycolysis. In Cellular oncology (Dordrecht, Netherlands), 45, 1383-1399. doi:10.1007/s13402-022-00726-0. https://pubmed.ncbi.nlm.nih.gov/36223033/

2. Tian, Xiang'an, Yang, Chengju, Yang, Liguang, Sun, Qinli, Liu, Naiqing. 2018. PTPRF as a novel tumor suppressor through deactivation of ERK1/2 signaling in gastric adenocarcinoma. In OncoTargets and therapy, 11, 7795-7803. doi:10.2147/OTT.S178152. https://pubmed.ncbi.nlm.nih.gov/30464527/

3. Xu, Y-Y, Liu, H, Su, L, Bed-David, Y, Li, Y-J. . PPARγ inhibits breast cancer progression by upregulating PTPRF expression. In European review for medical and pharmacological sciences, 23, 9965-9977. doi:10.26355/eurrev_201911_19563. https://pubmed.ncbi.nlm.nih.gov/31799666/

4. Wang, Yuhao, Shan, Aijun, Zhou, Zhiwei, Du, Bo, Lei, Bingxi. . LncRNA TCONS_00004099-derived microRNA regulates oncogenesis through PTPRF in gliomas. In Annals of translational medicine, 9, 1023. doi:10.21037/atm-21-2442. https://pubmed.ncbi.nlm.nih.gov/34277823/

5. Soulières, Denis, Hirsch, Fred R, Shepherd, Frances A, Shames, David S, Klughammer, Barbara. . PTPRF Expression as a Potential Prognostic/Predictive Marker for Treatment with Erlotinib in Non-Small-Cell Lung Cancer. In Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 10, 1364-1369. doi:10.1097/JTO.0000000000000624. https://pubmed.ncbi.nlm.nih.gov/26291013/

6. Borck, Guntram, de Vries, Liat, Wu, Hsin-Jung, Kubisch, Christian, Basel-Vanagaite, Lina. 2014. Homozygous truncating PTPRF mutation causes athelia. In Human genetics, 133, 1041-7. doi:10.1007/s00439-014-1445-1. https://pubmed.ncbi.nlm.nih.gov/24781087/

7. Zhao, Weiwei, Gong, Yanxuan, Chen, Yugang. 2022. MRNA Profiling Involved in Triggering of STAT1 with Regulatory Involvement of IRF7, PTPRF, and miR-145p in Patients Suffering from Gall Bladder Carcinoma. In Journal of healthcare engineering, 2022, 1770643. doi:10.1155/2022/1770643. https://pubmed.ncbi.nlm.nih.gov/35035811/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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