C57BL/6JCya-Ptprgem1/Cya
Common Name
Ptprg-KO
Product ID
S-KO-03927
Backgroud
C57BL/6JCya
Strain ID
KOCMP-19270-Ptprg-B6J-VA
When using this mouse strain in a publication, please cite “Ptprg-KO Mouse (Catalog S-KO-03927) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ptprg-KO
Strain ID
KOCMP-19270-Ptprg-B6J-VA
Gene Name
Product ID
S-KO-03927
Gene Alias
RPTPgamma, 5430405N12Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000248537
NCBI RefSeq
NM_008981
Target Region
Exon 7~29
Size of Effective Region
~127.2 kb
Overview of Gene Research
Ptprg, or Protein Tyrosine Phosphatase Receptor Type G, is a gene that interacts with and regulates several tyrosine kinases, exerting a tumor suppressor role in several types of cancers [2]. It contains a carbonic anhydrase-like domain and a fibronectin type III domain which are associated with [HCO3-] sensing in vascular and renal tissues and cell adhesion respectively. The contactins family has been identified as possible interactors of PTPRG [2]. It is also potentially related to inflammatory processes and could serve as an inflammatory marker [2].
In Alzheimer's disease (AD), single-cell and spatial transcriptomics studies show that the microglia subpopulation Mic_PTPRG can communicate with specific neurons, causing them to express PTPRG during AD progression. Within neurons, PTPRG binds and upregulates the m6A methyltransferase VIRMA, inhibiting translation of PRKN mRNA and suppressing mitophagy. As the disease progresses, this leads to the reprogramming of energy and nutrient metabolic pathways in neurons, resulting in their death [1].
In summary, Ptprg has important functions in cancer and neurodegenerative diseases. In cancer, it acts as a tumor suppressor. In AD, Ptprg-mediated regulation of VIRMA and subsequent inhibition of mitophagy in neurons is a potential pathway through which microglia and neuronal Ptprg modify neuronal connections during disease progression. These findings from in vivo-like studies in mouse models of AD help us understand the role of Ptprg in disease-related biological processes and potentially guide the development of therapies for these conditions [1,2].
References:
1. Zou, Donghua, Huang, Xiaohua, Lan, Yating, Mao, Yingwei, Luo, Jiefeng. 2024. Single-cell and spatial transcriptomics reveals that PTPRG activates the m6A methyltransferase VIRMA to block mitophagy-mediated neuronal death in Alzheimer's disease. In Pharmacological research, 201, 107098. doi:10.1016/j.phrs.2024.107098. https://pubmed.ncbi.nlm.nih.gov/38325728/
2. Boni, Christian, Laudanna, Carlo, Sorio, Claudio. 2022. A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease. In Biomolecules, 12, . doi:10.3390/biom12010084. https://pubmed.ncbi.nlm.nih.gov/35053232/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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