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C57BL/6JCya-Zfp3em1/Cya
Common Name:
Zfp3-KO
Product ID:
S-KO-03960
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Zfp3-KO
Strain ID
KOCMP-193043-Zfp3-B6J-VA
Gene Name
Zfp3
Product ID
S-KO-03960
Gene Alias
B230309J24; Fnp-1; Zfp-3
Background
C57BL/6JCya
NCBI ID
193043
Modification
Conventional knockout
Chromosome
11
Phenotype
MGI:99177
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Zfp3em1/Cya mice (Catalog S-KO-03960) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000060444
NCBI RefSeq
NM_177565
Target Region
Exon 2
Size of Effective Region
~2.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Zfp3, a C2H2-type zinc finger protein gene, has been shown to play crucial roles in plants and potentially in human diseases. In plants like Arabidopsis thaliana, it is involved in multiple biological processes such as salt and osmotic stress response, vegetative growth, root hair development, and regulation of abscisic acid (ABA) and light signaling during seed germination and early seedling development [1,2,4]. In human-related research, it may be associated with diseases like non-small cell lung cancer (NSCLC), tongue squamous cell carcinoma (TSCC), heart failure, and clear cell renal cell carcinoma (ccRCC), and is also potentially involved in the regulation of isoflavonoid biosynthesis in woody plants [3,5,6,7,8].

In Arabidopsis, constitutive expression of Zfp3 enhanced tolerance to salt and osmotic stress, while the zfp3 mutant plants showed reduced tolerance. This indicates its role in stress-related physiological changes such as proline accumulation and chlorophyll content regulation, and it also induced the expressions of stress-related genes like KIN1, RD22, RD29B, and AtP5CS1 [1]. Zfp3 overexpression in Arabidopsis reduced plant growth, limited cell expansion in leaves, and compromised root hair development, suggesting its function in vegetative growth regulation [2]. In seed germination, Zfp3 acts as a negative regulator of ABA-suppression of seed germination, as Zfp3 overexpression lines showed ABA insensitivity, while the zfp3 zfp4 double mutant had enhanced ABA susceptibility [4].

In conclusion, Zfp3 is an important gene with diverse functions. In plants, it significantly influences stress responses, growth, and development. In human-related diseases, although more research is needed, its potential association with various cancers and heart failure implies its importance in understanding disease mechanisms. The study of Zfp3 in genetic models like Arabidopsis mutants has provided valuable insights into its functions, and further research may help clarify its role in human diseases.

References:

1. Zhang, Aidong, Liu, Dongdong, Hua, Changmei, Ali, Imran, Gan, Yinbo. 2016. The Arabidopsis Gene zinc finger protein 3(ZFP3) Is Involved in Salt Stress and Osmotic Stress Response. In PloS one, 11, e0168367. doi:10.1371/journal.pone.0168367. https://pubmed.ncbi.nlm.nih.gov/27977750/

2. Benyó, Dániel, Bató, Emese, Faragó, Dóra, Nagy, István, Szabados, László. 2024. The zinc finger protein 3 of Arabidopsis thaliana regulates vegetative growth and root hair development. In Frontiers in plant science, 14, 1221519. doi:10.3389/fpls.2023.1221519. https://pubmed.ncbi.nlm.nih.gov/38250442/

3. Wang, Yue, Cao, Shuhui, Li, Jingwen, Zhou, Yan, Zhong, Hua. 2023. The predictive value of plasma exosomal lncRNAs/mRNAs in NSCLC patients receiving immunotherapy. In Advances in medical sciences, 68, 86-93. doi:10.1016/j.advms.2023.01.003. https://pubmed.ncbi.nlm.nih.gov/36801676/

4. Joseph, Mary Prathiba, Papdi, Csaba, Kozma-Bognár, László, Koncz, Csaba, Szabados, László. 2014. The Arabidopsis ZINC FINGER PROTEIN3 Interferes with Abscisic Acid and Light Signaling in Seed Germination and Plant Development. In Plant physiology, 165, 1203-1220. doi:. https://pubmed.ncbi.nlm.nih.gov/24808098/

5. Jin, Yi, Wang, Zhanwang, Tang, Weizhi, Wu, Xiangwei, Wang, Hui. 2022. An Integrated Analysis of Prognostic Signature and Immune Microenvironment in Tongue Squamous Cell Carcinoma. In Frontiers in oncology, 12, 891716. doi:10.3389/fonc.2022.891716. https://pubmed.ncbi.nlm.nih.gov/35912229/

6. Andersson, Charlotte, Lin, Honghuang, Liu, Chunyu, Larson, Martin G, Vasan, Ramachandran S. 2019. Integrated Multiomics Approach to Identify Genetic Underpinnings of Heart Failure and Its Echocardiographic Precursors: Framingham Heart Study. In Circulation. Genomic and precision medicine, 12, e002489. doi:10.1161/CIRCGEN.118.002489. https://pubmed.ncbi.nlm.nih.gov/31703168/

7. Yang, Juan, Yang, Jin, Gao, Yan, Song, Tusheng, Huang, Chen. 2014. Identification of potential serum proteomic biomarkers for clear cell renal cell carcinoma. In PloS one, 9, e111364. doi:10.1371/journal.pone.0111364. https://pubmed.ncbi.nlm.nih.gov/25368985/

8. Wang, Jiaqi, Li, Lu, Wang, Zhihua, Deng, Xiaomei, Wu, Ai-Min. 2023. Integrative analysis of the metabolome and transcriptome reveals the molecular regulatory mechanism of isoflavonoid biosynthesis in Ormosia henryi Prain. In International journal of biological macromolecules, 246, 125601. doi:10.1016/j.ijbiomac.2023.125601. https://pubmed.ncbi.nlm.nih.gov/37392916/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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